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Eosinophils Interaction with Mast Cells: The Allergic Effector Unit

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Eosinophils

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1178))

Abstract

Mast cells (MC) and eosinophils are the key effector cells of allergy (Minai-Fleminger and Levi-Schaffer, Inflamm Res 58:631–638, 2009). In general, allergic reactions have two phases, namely, an early phase and a late phase. MC and eosinophils abundantly coexist in the inflamed tissue in the late and chronic phases and cross talk in a bidirectional manner. This bidirectional interaction between MC and eosinophils is mediated by both physical cell–cell contacts through cell surface receptors such as CD48 , 2B4 and soluble mediators through various specific granular mediators, arachidonic acid metabolites, cytokines , and chemokines, collectively termed the “Allergic Effector Unit” (AEU) (Elishmereni et al., Allergy 66:376–385, 2011; Minai-Fleminger et al., Cell Tissue Res 341:405–415, 2010). These bidirectional interactions can be studied in vitro in a customized coculture system of MC and eosinophils derived from either mouse or human source.

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Acknowledgements

The authors would like to thank to Laila Karra for her valuable comments and critical evaluation in writing this chapter. This work was supported by the Israel Science Foundation (grant 213/05), the MAARS EU 7th framework (grant no. HEALTH-F2-2011-261366), the Aimwell Charitable Trust (London, UK). F. Levi-Schaffer is affiliated with The Dr. Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics, School of Pharmacy and the Alex Grass Center for Drug Design and Synthesis of Novel Therapeutics, School of Pharmacy of The Hebrew University of Jerusalem.

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 12065, Jerusalem, 91120, Israel

    Roopesh Singh Gangwar

  2. Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, 12065, Jerusalem, 91120, Israel

    Francesca Levi-Schaffer

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  1. Roopesh Singh Gangwar
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  2. Francesca Levi-Schaffer
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Correspondence to Francesca Levi-Schaffer .

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Editors and Affiliations

  1. Division of Applied Medicine, University of Aberdeen Institute of Medical Sciences, Aberdeen, United Kingdom

    Garry M. Walsh

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Gangwar, R.S., Levi-Schaffer, F. (2014). Eosinophils Interaction with Mast Cells: The Allergic Effector Unit. In: Walsh, G. (eds) Eosinophils. Methods in Molecular Biology, vol 1178. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1016-8_20

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  • DOI: https://doi.org/10.1007/978-1-4939-1016-8_20

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1015-1

  • Online ISBN: 978-1-4939-1016-8

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