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Update on Eosinophil Interaction with Mast Cells: The Allergic Effector Unit

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Eosinophils

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2241))

Abstract

Mast cells and eosinophils are the key effector cells of allergy [1]. In general, allergic reactions are composed of two phases, namely an early phase and a late phase, and after that resolution occurs. If the allergic reactions fail to resolve after the late phase, allergic inflammation (AI) can evolve into a chronic phase mainly involving mast cells and eosinophils that abundantly coexist in the inflamed tissue in the late and chronic phases and cross-talk in a bidirectional manner. We defined these bidirectional interactions between MCs and Eos, as the “allergic effector unit.” This cross talk is mediated by both physical cell-cell contacts through cell surface receptors such as CD48, 2B4, and respective ligands and through released mediators such as various specific granular mediators, arachidonic acid metabolites, cytokines, and chemokines [2, 3]. The allergic effector unit can be studied in vitro in a customized co-culture system using mast cells and eosinophils derived from either mouse or human sources.

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Acknowledgments

This work was supported by the Israel Science Foundation and Aimwell Charitable Trust (London, UK). F. Levi-Schaffer is affiliated with the Dr. Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics, School of Pharmacy of the Hebrew University of Jerusalem.

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Authors and Affiliations

  1. Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Roopesh Singh Gangwar, Hadas Pahima, Pier Giorgio Puzzovio & Francesca Levi-Schaffer

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  1. Roopesh Singh Gangwar
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  2. Hadas Pahima
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  3. Pier Giorgio Puzzovio
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  4. Francesca Levi-Schaffer
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Correspondence to Francesca Levi-Schaffer .

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  1. Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK

    Garry M. Walsh

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Gangwar, R.S., Pahima, H., Puzzovio, P.G., Levi-Schaffer, F. (2021). Update on Eosinophil Interaction with Mast Cells: The Allergic Effector Unit. In: Walsh, G.M. (eds) Eosinophils. Methods in Molecular Biology, vol 2241. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1095-4_18

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  • DOI: https://doi.org/10.1007/978-1-0716-1095-4_18

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