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Isolation of immunogenic tumour cells by cell-affinity chromatography

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Abstract

TUMOUR–HOST relationships are determined by many variables1,2, and may be altered to favour the host by the use of chemically modified cells which act as specific immunostimulants3. Furthermore, modified cells have therapeutic value in mice with small tumours4,5. Several studies have shown that conventional methods followed by administration of immunostimulants are very effective in treating tumours and inducing tumour-specific immunity6–8. Combined chemotherapy and immunotherapy of L1210 leukaemia with neuraminidase-treated (VCN) tumour cells yielded a higher percentage of long term survivors than did chemotherapy alone6,7,9,10. The therapeutic effectiveness of VCN-treated cells depended on several variables10, including proper selection of immunogenic cells7,11.

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Authors and Affiliations

  1. Cancer Section, Oklahoma Medical Research Foundation and Department of Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104

    JERALD J. KILLION & G. MARK KOLLMORGEN

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  1. JERALD J. KILLION
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  2. G. MARK KOLLMORGEN
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KILLION, J., KOLLMORGEN, G. Isolation of immunogenic tumour cells by cell-affinity chromatography. Nature 259, 674–676 (1976). https://doi.org/10.1038/259674a0

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  • DOI: https://doi.org/10.1038/259674a0

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