Abstract
THE lymph node cells of mice rendered unresponsive by the injection of picryl sulphonic acid (PSA) depress the passive transfer of contact sensitivity1. When the mice are also painted with picryl chloride the lymph node cells produce suppressor factor in vitro. This factor depresses the passive transfer of contact sensitivity by immune cells and its production is T-cell dependent2. Here we show that suppressor factor(s) has a molecular weight ∼50,000 and that it is absorbed by and can be eluted from specific antigen in the form of picrylated albumin attached to Sepharose beads.
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References
Zembala, M., and Asherson, G. L., Nature, 244, 227–228 (1973).
Asherson, G. L., and Zembala, M., Eur. J. Immun. (in the press).
Axen, R., Porath, J., and Ernback, S., Nature, 214, 1302–1304 (1967).
Ramseier, H., and Lindenmann, J., Trans. Rev., 10, 57–96 (1972).
Okumura, K., and Tada, T., J. Immun., 112, 783–791 (1973).
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ZEMBALA, M., ASHERSON, G., MAYHEW, B. et al. In vitro absorption and molecular weight of specific T-cell suppressor factor. Nature 253, 72–74 (1975). https://doi.org/10.1038/253072a0
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DOI: https://doi.org/10.1038/253072a0
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