Abstract
WHEN parathyroid hormone is infused chronically at a near-physiological rate, it causes hypercalcaemia by a mechanism fundamentally different from that which follows acute injections. Hormones, like drugs, have characteristic rates of metabolism and excretion and their distribution in the body is affected by binding to plasma proteins and membranes. Thus similar dependence of the pattern of response on entry rate is to be expected in the case of other hormones with short half lives, acting on multiple receptors of varying sensitivity.
Similar content being viewed by others
References
Parsons, J. A., and Potts, J. T., jun., Clin. Endocr. Metab., 1, No. 1, 33 (1972).
Sharpe, J., Lewin, J., and Parsons, J. A., Lancet (in the press).
Parsons, J. A., Neer, R. M., and Potts, J. T., jun., Endocrinology, 89, 735 (1971).
Parsons, J. A., Darby, A. J., and Reit, B., in Endocrinology 1973 (edit. by Taylor, S.) (Heinemann Medical Books, London, in the press).
Reit, B., Rafferty, B., and Parsons, J. A., in tenth Eur. Symp. Calcified Tissues (edit. by Kuhlencordt, F.) (Springer, Berlin, in the press).
Parsons, J. A., Reit, B., and Robinson, C. J., Endocrinology, 92, 454 (1973).
Parsons, J. A., Dawson, B., Callahan, E., and Potts, J. T., jun., Biochem. J., 119, 791 (1970).
Potts, J. T., jun., Keutmann, H. T., Niall, H. D., Deftos, L. J., Brewer, H. B., and Aurbach, G. D., in Parathyroid hormone and Thyrocalcitonin (Calcitonin) (edit. by Talmage, R. V., and Belanger, L. F.), 44 (Excerpta Medica, Amsterdam, 1968).
Silverman, R., and Yalow, R. S., J. clin. Invest., 52, 1958 (1973).
Segre, G. V., Niall, H. D., Habener, J. F., and Potts, J. T., jun., Am. J. Med., 56, 774 (1974).
Potts, J. T., jun., Murray, T. M., Peacock, M., Niall, H. D., Tregear, G. W., Keutmann, H. T., Powell, D., and Deftos, L. J., Am. J. Med., 50, 639 (1971).
Habener, J. F., Segre, G. V., Powell, D., and Potts, J. T., jun., Nature new Biol., 238, 152 (1972).
Segre, G. V., Habener, J. F., Powell, D., Tregear, G. W., and Potts, J. T., jun., J. clin. Invest., 51, 3163 (1972).
Care, A. D., Sherwood, L. M., Potts, J. T., jun., and Aurbach, G. D., Nature, 209, 55 (1966).
Copp, D. H., Moghadam, H., Mensen, E. D., and McPherson, G. D., in The parathyroids (edit. by Greep, R. O., and Talmage, R. V.), 203 (Thomas, Springfield, Illinois, 1961).
LeRoy, E. C., Kaplan, A., Udenfriend, S., and Sjoerdsma, A., J. biol. Chem., 239, 3350 (1964).
Bates, W. K., McGowen, J., and Talmage, R. V., Endocrinology, 71, 189 (1962).
Harris, E. D., and Sjoerdsma, A., J. clin. Endocr., 26, 358 (1966).
Chase, L. R., Fedak, S. A., and Aurbach, G. D., Endocrinology, 84, 761 (1969).
De Grazia, J. A., Ivanovitch, P., Fellows, H., and Rich, C., J. Lab. clin. Med., 66, 822 (1965).
Omdahl, J. L., and Deluca, H. F., Physiol. Rev., 53, 327 (1973).
Avioli, L. V., and Haddad, J. G., Metabolism, 22, 507 (1973).
Wasserman, R. H., and Taylor, A. N., in Mineral metabolism (edit. by Comar, C. L., and Bronner, F.), 111, 321 (Academic Press, New York, 1969).
Agus, Z. S., Gardner, L. B., Beck, L. H., and Goldberg, M., Am. J. Physiol., 224, 1143 (1973).
Agus, Z. A., Puschett, J. B., Senesky, D., and Goldberg, M., J. clin. invest., 50, 617 (1971).
Treacher, R. J., J. Endocr., 35, 229 (1965).
Selye, H., Endocrinology, 16, 547 (1932).
Kalu, D. N., Pennock, J., Doyle, F. H., and Foster, G. V., Lancet, i, 1363 (1970).
Walker, D. G., Endocrinology, 89, 1389 (1971).
O'Riordan, J. L. H., Watson, L., and Woodhead, J. S., Clin. Endocr., 1, 149 (1972).
Stanbury, S. W., Mawer, E. B., Lumb, G. A., Hill, L. F., Holman, C. A., Taylor, C. M., and Torkington, P., in Clinical Aspects of Metabolic Bone Disease (edit. by Duncan, J., and Frame, B.) 562 (Excerpta Medica, Amsterdam, 1973).
Connor, T. B., Stoner, R. E., Freijanes, J., Martin, L. G., and Jowsey, J., Trans. Am. clin. climatol. Asso. (in the press).
Doyle, F. H., Br. med. Bull., 28, 220 (1972).
Robinson, C. J., Rafferty, B., and Parsons, J. A., Clin. Sci., 42, 235 (1972).
Brazeau, P., in The Pharmacological Basis of Therapeutics (edit. by Goodman, L. S., and Gilman, A.) 4th ed. 880 (Macmillan, New York, 1970).
Lauson, H. D., Am. J. Med., 42, 713 (1967).
Yamaji, T., Dierschke, D. J., Hotchkiss, J., Bhattacharya, A. H., Surve, A. H., and Knobil, E., Endocrinology, 89, 1034 (1971).
Karsch, F. J., Dierschke, D. J., Weick, R. F., Yamaji, T., Hotchkiss, J., and Knobil, E., Endocrinology, 92, 799 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PARSONS, J., REIT, B. Chronic response of dogs to parathyroid hormone infusion. Nature 250, 254–257 (1974). https://doi.org/10.1038/250254a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/250254a0
- Springer Nature Limited
This article is cited by
-
Present at the beginning: a personal reminiscence on the history of teriparatide
Osteoporosis International (2011)
-
Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration
Nature Medicine (1999)
-
Synthetic parathyroid hormone-like protein (1?74) is anabolic for bone in vivo
Calcified Tissue International (1992)
-
Increase of vertebral density by combination therapy with pulsatile 1-38hPTH and sequential addition of calcitonin nasal spray in osteoporotic patients
Calcified Tissue International (1989)