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Parathyroid Hormones

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

The primary function of parathyroid hormone (PTH) is to maintain a constant concentration of Ca2+ in the extracellular fluid. Processes that are regulated include the absorption of Ca2+ from the gastrointestinal tract, the deposition and mobilization of bone Ca2+, and the excretion of Ca2+ in urine, feces, sweat, and milk. PTH is the functional antagonist of calcitonin. The most prominent effect is to promote the mobilization of Ca2+ from the bone. In the kidney, the tubular reabsorption of Ca2+ is increased and tubular reabsorption of phosphate is inhibited. Clinically, idiopathic or postoperative hypoparathyroidism results in hypocalcemia followed by tetany.

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References and Further Reading

General Considerations

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  1. Frankfurt-Main University, Centre of Pharmacology, Glashuetten, Germany

    Jürgen Sandow

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  1. Jürgen Sandow
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Correspondence to Jürgen Sandow .

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  1. Dieburg, Germany

    Franz J. Hock

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Sandow, J. (2015). Parathyroid Hormones. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_80-1

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