Abstract
Parathyroid hormone is responsible for calcium homeostasis. Hypocalcaemia activates the calcium-sensing receptor on the surface of the parathyroid cell to release parathyroid hormone, which directly acts on the skeleton mobilising calcium from the bone. It directly stimulates Ca2+ reabsorption from the distal convoluted tubules of the kidneys and acts on the kidneys increasing the conversion of 25-hydroxy vitamin D to its active form of 1,25-dihydroxy vitamin D, which increases calcium absorption by the proximal tubules and the gut, and promotes calcium reabsorption in the ascending limb of loop of Henle, distal tubule, and collecting tubule. These actions lead to increased plasma Ca2+ levels.
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Siraj, Q.H., Rasulova, N. (2019). Physiology. In: Siraj, Q. (eds) Radionuclide Parathyroid Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-17351-7_2
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DOI: https://doi.org/10.1007/978-3-030-17351-7_2
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