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Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat

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Abstract

NEUROPHYSIOLOGICAL experiments suggest that several aminoacids, especially glycine and glutamic, aspartic and gamma-aminobutyric (GABA) acids, are neurotransmitters in the central nervous system1–3. But careful subcellular4,5 and regional studies6–8 have not provided supporting neurochemical evidence, because ammo-acids, with the possible exception of GABA, also have general metabolic functions in nervous tissue.

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LOGAN, W., SNYDER, S. Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat. Nature 234, 297–299 (1971). https://doi.org/10.1038/234297b0

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