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Rabbit Antibody Light Chains and Gene Evolution

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Abstract

Several amino-acid positions in the light chains of rabbits are different from the same positions in the light chains of man. This observation suggests that rapid gene expansion is a fundamental mechanism in the evolution of the immune system.

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References

  1. Edelman, G., and Gall, W. E., Ann. Rev. Biochem., 38, 415 (1969).

    Article  CAS  PubMed  Google Scholar 

  2. Putnam, F. W., Science, 163, 633 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Proc. Symp. Developmental Aspects of Antibody Formation and Structure (edit. by Sterzl, J., and Rhia, H.) (Academic Press, New York, in the press).

  4. Hood, L., and Talmage, D., Science, 168, 325 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Milstein, C., and Piub, J., Prog. Biophys. Mol. Biol., 21, 211 (1970).

    Article  Google Scholar 

  6. Milstein, C., Biochem. J., 101, 338 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Baglioni, C., Zonta, L. A., Cioli, D., and Carbonara, A., Science, 152, 1517 (1967).

    Article  ADS  Google Scholar 

  8. Ropartz, C., and Lenoir, J., Nature, 189, 586 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Terry, W. T., Hood, L., and Steinberg, A. G., Proc. US Nat. Acad. Sci., 63, 71 (1969).

    Article  ADS  CAS  Google Scholar 

  10. Dreyer, W. J., and Bennett, J. C., Proc. US Nat. Acad. Sci., 54, 864 (1965).

    Article  ADS  CAS  Google Scholar 

  11. Dreyer, W. J., Gray, W. R., and Hood, L., Cold Spring Harbor Symp. Quant. Biol., 32, 353 (1967).

    Article  CAS  Google Scholar 

  12. Hood, L., Gray, W. R., Sanders, B. G., and Dreyer, W. J., Cold Spring Harbor Symp. Quant. Biol., 32, 133 (1967).

    Article  CAS  Google Scholar 

  13. Milstein, C., Milstein, C. P., and Jarvis, J. M., J. Mol. Biol., 46, 599 (1969).

    Article  CAS  PubMed  Google Scholar 

  14. Milstein, C., Nature, 216, 330 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Langer, Von B., Steinmetz-Kayne, M., and Hilschmann, N., Z. Physiol. Chem., 349, 945 (1968).

    CAS  Google Scholar 

  16. Hood, L., and Ein, D., Nature, 220, 764 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Cunningham, B. A., Pflummer, M. N., Rutishauser, V., and Edelman, G. M., Proc. US Nat. Acad. Sci., 64, 997 (1969).

    Article  ADS  CAS  Google Scholar 

  18. Press, E. M., and Hogg, N. M., Nature, 223, 807 (1969).

    Article  ADS  CAS  Google Scholar 

  19. Doolittle, R. F., Proc. US Nat. Acad. Sci., 55, 1195 (1966).

    Article  ADS  CAS  Google Scholar 

  20. Osterland, C. D., Miller, E. J., Karakawa, W. W., and Krause, R. M., J. Exp. Med., 123, 599 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Braun, D. G., Eichmann, K., and Krause, R. M., J. Exp. Med., 129, 809 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Hood, L., Lackland, H., Eichmann, K., Kindt, T. J., Braun, D. G., and Krause, R. M., Proc. US Nat. Acad. Sci., 63, 890 (1970).

    Article  ADS  Google Scholar 

  23. Eichmann, K., Lackland, H., Hood, L., and Krause, R. M., J. Exp. Med., 131, 207 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Kindt, T. J., Todd, C. W., Eichmann, K., and Krause, R. M., J. Exp. Med., 131, 343 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. McCarty, M., J. Exp. Med., 108, 311 (1958).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Krause, R. M., and McCarty, M., J. Exp. Med., 115, 49 (1962).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Eichmann, K., Braun, D. G., Feizi, T., and Krause, R. M., J. Exp. Med., 131, 1169 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Oudin, J., J. Exp. Med., 112, 107 (1960).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Edman, P., and Begg, G., Europ. J. Biochem., 1, 80 (1967).

    Article  CAS  PubMed  Google Scholar 

  30. Pisano, J., and Bronzert, T., J. Biol. Chem., 24, 5597 (1969).

    Google Scholar 

  31. Van Orden, H. O., and Carpenter, F. H., Biochem. Biophys. Res. Commun., 14, 399 (1964).

    Article  CAS  PubMed  Google Scholar 

  32. Dreyer, W. J., and Bynum, E., Methods in Emymology, 11, 32 (1967).

    Article  CAS  Google Scholar 

  33. Jaton, J. C., Waterfield, M. D., Margolis, M., and Haber, E., Proc. US Nat. Acad. Sci. (in the press).

  34. Hood, L., Potter, M., and McKean, D. (in the press).

  35. Hood, L., Grant, J. A., Sox, H. C., Proc. Symp. Developmental Aspects of Antibody Formation and Structure (edit. by Sterzl, J., and Rhea, H.) (Academic Press, New York, in the press).

  36. Britten, R. J., and Kohne, D. E., Science, 161, 529 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  37. Britten, R. J., Carnegie Institute Wash. Year Book, 68, 376 (1969).

    Google Scholar 

  38. Rittossa, F., Atwood, K., Lindsley, D., and Spiegelman, S., Nat. Cancer Inst. Monog., 23, 449 (1966).

    Google Scholar 

  39. Retel, J., and Planta, R. J., Biochim. Biophys. Acta, 169, 416 (1968).

    Article  CAS  PubMed  Google Scholar 

  40. Ritossa, F. M., and Spiegelman, S., Proc. US Nat. Acad. Sci., 53, 737 (1965).

    Article  ADS  CAS  Google Scholar 

  41. Wallace, H., and Bernstel, M., Biochim. Biophys. Acta, 114, 296 (1966).

    Article  CAS  PubMed  Google Scholar 

  42. Chipchase, M. I. H., and Bernstiel, M. J., Proc. US Nat. Acad. Sci., 50, 1101 (1963).

    Article  ADS  CAS  Google Scholar 

  43. Attardi, G., Huang, P-C., and Kabat, S., Proc. US Nat. Acad. Sci., 54, 185 (1965).

    Article  ADS  CAS  Google Scholar 

  44. Brown, D. D., and Weber, C. S., J. Mol. Biol., 34, 661 (1968).

    Article  CAS  PubMed  Google Scholar 

  45. Pinder, J. C., Gould, H. J., and Smith, I., J. Mol. Biol., 40, 289 (1969).

    Article  CAS  PubMed  Google Scholar 

  46. Perry, E., Cheng, T. Y., Freed, J. J., Greenberg, J. R., Kelly, D. E., and Tartof, K. P., Proc. US Nat. Acad. Sci., 65, 609 (1970).

    Article  ADS  CAS  Google Scholar 

  47. McCarthy, B. J., Handbook of Molecular Cytology (edit. by Lima-de-Faria, A.), 13 (North-Holland, Amsterdam, 1969).

    Google Scholar 

  48. Hennig, W., and Walker, P. M. B., Nature, 225, 915 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  49. Brown, D. D., and Gurdon, J. B., Proc. US Nat. Acad. Sci., 51, 139 (1964).

    Article  ADS  CAS  Google Scholar 

  50. Callan, J. D., J. Cell Sci., 2, 1 (1967).

    CAS  PubMed  Google Scholar 

  51. Edelman, G. M., and Gally, J. A., The Neurosciences: Second Study Program (edit. by Schmitt, F. O.) (Rockefeller Univ. Press, New York, in the press).

  52. Gally, J. A., and Edelman, G. M., Nature, 227, 341 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  53. Walker, P. M. B., Flamm, W. G., and McLaren, A., Handbook of Molecular Cytology (edit. by Lima-de-Faria, A.), 53 (North-Holland, Amsterdam, 1969).

    Google Scholar 

  54. Atkin, N. B., Mattinson, G., Becak, W., and Ohno, S., Chromosoma, 17, 1 (1965).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. California Institute of Technology, Department of Biology, Pasadena, California, 91109

    LEROY HOOD

  2. The Rockefeller University, New York, 10021

    KLAUS EICHMANN, HENRY LACKLAND & RICHARD M. KRAUSE

  3. Beckman Instrument Company, Palo Alto, California

    JACK J. OHMS

Authors
  1. LEROY HOOD
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  2. KLAUS EICHMANN
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  3. HENRY LACKLAND
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  4. RICHARD M. KRAUSE
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  5. JACK J. OHMS
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HOOD, L., EICHMANN, K., LACKLAND, H. et al. Rabbit Antibody Light Chains and Gene Evolution. Nature 228, 1040–1044 (1970). https://doi.org/10.1038/2281040a0

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  • DOI: https://doi.org/10.1038/2281040a0

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