Abstract
Comparison of the NH2-terminal region of several α, γ and μ chains indicates that four variable-sequence subgroups are common to heavy chains. The existence of three independent variable-gene pools common to the three major immunoglobulin classes is confirmed.
Similar content being viewed by others
References
Bull. World Health Org., 30, 447 (1964).
Putnam, F. W., Science, 163, 633 (1969).
Hill, R. L., Delaney, R., Fellows, jun., R. E., and Lebowitz, H. E., Proc. US Nat. Acad. Sci., 56, 1762 (1966).
Todd, C. W., Biochem. Biophys. Res. Commun., 11, 170 (1963).
Wikler, M., Köhler, H., Shinoda, T., and Putnam, F. W., Science, 163, 75 (1969).
Press, E. M., and Hogg, N. M., Nature, 223, 807 (1969).
Köhler, H., Shimizu, A., Paul, C., and Putnam, F. W., Science (in the press).
Cunningham, B. A., Pflumm, M. N., Rutishauser, U., and Edelman, G. M., Proc. US Nat. Acad. Sci., 64, 997 (1969).
Porter, R. R., Biochem. J., 105, 417 (1967).
Putnam, F. W., Kozuru, M., and Easley, C. W., J. Biol. Chem., 242, 2435 (1967).
Press, E. M., Piggott, P. J., and Porter, R. R., Biochem. J., 99, 1356 (1966).
Gray, W. R., and Hartley, B. S., Biochem. J., 89, 379 (1963).
Edman, P., and Begg, C., Europ. J. Biochem., 1, 80 (1967).
Jeppson, J. O., and Sjöquist, J., Anal. Biochem., 18, 264 (1967).
Pisano, J. J., and Bronzent, T. J., J. Biol. Chem., 244, 5597 (1969).
Edelman, G. M., Cunningham, B. A., Gall, W. E., Gottlieb, P. D., Rutishauser, V., and Waxdal, M. J., Proc. US Nat. Acad. Sci., 53, 78 (1969).
Frangione, B., and Milstein, C., Nature, 224, 597 (1969).
Fisher, C. E., Palm, W. H., and Press, E. M., FEBS Letters, 5, 201 (1969).
Press, E. M., and Hogg, N. M., Biochem. J. (in the press, 1970).
Pink, J. R. L., and Milstein, C., FEBS Symp., 15, 177 (1969).
Wilkinson, J. M., Biochem. J., 112, 173 (1969).
Bennett, J. C., Biochemistry, 7, 3340 (1968).
Putnam, F. W., and Köhler, H., Naturwissenschaften, 56, 739 (1969).
An Extension of the Nomenclature for Immunoglobulins. Bull. World Health Org., 41, 975 (1969).
Putnam, F. W., Shinoda, T., Titani, K., and Wikler, M., Science, 157, 1050 (1967).
Feinstein, A., Nature, 199, 1197 (1963).
Kelus, A. S., and Gell, P. G. H., Progress in Allergy, 11, 141 (1967).
Milstein, C., and Pink, J. R. L., Progress in Biophys. Mol. Biol., 21, 209 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KÖHLER, H., SHIMIZU, A., PAUL, C. et al. Three Variable-Gene Pools common to IgM, IgG and IgA Immunoglobulins. Nature 227, 1318–1320 (1970). https://doi.org/10.1038/2271318a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2271318a0
- Springer Nature Limited
This article is cited by
-
The murine kappa light chain shift
Nature (1978)
-
N-terminal sequences of secretory piece and of α chains of different allotype in rabbit secretory IgA
Nature (1975)
-
Die Entwicklung des Immunsystems
Klinische Wochenschrift (1974)