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Toxicity of Pyrrolizidine Alkaloids

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Abstract

A new class of metabolite, with a pyrrole-like structure, has been demonstrated in the tissues of animals poisoned by pyrrolizidine alkaloids. There is some correlation between the degree of hepato-toxicity and the amount of “pyrrole” found in the liver. Evidence has been found of the types of reactions such metabolites might undergo with tissue constituents.

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Authors and Affiliations

  1. Toxicology Research Unit, MRC Laboratories, Woodmansterne Road, Carshalton, Surrey

    A. R. MATTOCKS

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  1. A. R. MATTOCKS
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MATTOCKS, A. Toxicity of Pyrrolizidine Alkaloids. Nature 217, 723–728 (1968). https://doi.org/10.1038/217723a0

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  • DOI: https://doi.org/10.1038/217723a0

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