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Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones

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We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl4-induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.

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Authors and Affiliations

  1. Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    N. V. Tursunova, Yu. V. Tornuev & M. G. Klinnikova

  2. Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan

    V. N. Syrov & Z. A. Khushbaktova

Authors
  1. N. V. Tursunova
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  2. V. N. Syrov
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  3. Z. A. Khushbaktova
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  4. Yu. V. Tornuev
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  5. M. G. Klinnikova
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Corresponding author

Correspondence to N. V. Tursunova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 8, pp. 157-161, August, 2021

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Tursunova, N.V., Syrov, V.N., Khushbaktova, Z.A. et al. Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones. Bull Exp Biol Med 172, 133–136 (2021). https://doi.org/10.1007/s10517-021-05349-3

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  • DOI: https://doi.org/10.1007/s10517-021-05349-3

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