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Effects of [(1-phenyl-5-formyl-1H-imidazol-4-yl)thio]acetic Acid on the Antioxidant Status of the Liver and Kidney in Rats with Tetrachloromethane Poisoning

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Pharmaceutical Chemistry Journal Aims and scope

The effects of [(1-phenyl-5-formyl-1H-imidazol-4-yl)thio]acetic acid on oxidant-antioxidant homeostasis in rats with tetrachloromethane poisoning were studied. This compound was found to normalize most parameters of the oxidant-antioxidant balance in the liver and kidneys of animals with toxic hepatitis. These results point to the ability of compounds of this type to suppress free-radical lipid oxidation and oxidative protein modification processes and to activate the antioxidant protection system in animal tissues.

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Authors and Affiliations

  1. Bukovina State Medical University, Chernovtsy, Ukraine

    A. A. Palamar, I. N. Yaremii, V. A. Chornous & A. N. Grozav

  2. Institute of Organic Chemistry, Ukrainian National Academy of Sciences, Kiev, Ukraine

    M. V. Vovk

Authors
  1. A. A. Palamar
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  2. I. N. Yaremii
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  3. V. A. Chornous
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  4. A. N. Grozav
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  5. M. V. Vovk
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Corresponding author

Correspondence to A. A. Palamar.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 11, pp. 17 – 21, November, 2020.

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Palamar, A.A., Yaremii, I.N., Chornous, V.A. et al. Effects of [(1-phenyl-5-formyl-1H-imidazol-4-yl)thio]acetic Acid on the Antioxidant Status of the Liver and Kidney in Rats with Tetrachloromethane Poisoning. Pharm Chem J 54, 1101–1105 (2021). https://doi.org/10.1007/s11094-021-02328-w

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  • DOI: https://doi.org/10.1007/s11094-021-02328-w

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