Abstract
PHARMACOLOGICAL screening of a series of guanidines1, formally related to the quaternary ammonium anthelmintic compound bephenium and its congeners2, revealed that B.W. 712C60 [(I), R1 = R2 = phenyl; A = (CH2)2] although devoid of such anthelmintic activity antagonized 5-hydroxytryptamine (5HT).
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References
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COPP, F., GREEN, A., HODSON, H. et al. New Peripheral Antagonists of 5-Hydroxytryptamine. Nature 214, 200–201 (1967). https://doi.org/10.1038/214200a0
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DOI: https://doi.org/10.1038/214200a0
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