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The derivatives of imidazo[1,2-a]benzimidazole as 5-HT2A receptor antagonists

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Abstract

We studied in vitro the 5-HT2A antagonistic activity of 16 imidazo[1,2-a]benzimidazole derivatives. Using the radioligand method we showed the binding of 9-(2-diethylaminoethyl)-2-(4-methoxyphenyl)imidazo[1,2-a]benzimidazol dinitrate to the 2A subtype serotonin receptor.

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Authors and Affiliations

  1. Volgograd Medical Research Center, pl. Pavshikh Bortsov 1, Volgograd, 400131, Russia

    A. A. Spasov, D. S. Yakovlev, D. V. Maltsev & Y. V. Morkovina

  2. Volgograd State Medical University, pl. Pavshikh Bortsov 1, Volgograd, 400131, Russia

    A. A. Spasov, D. S. Yakovlev & D. V. Maltsev

  3. Research Institute of Physical and Organic Chemistry at Southern Federal University, pr. Stachky 194/2, Rostov-on-Don, 344090, Russia

    O. N. Zhukovskaya, V. A. Anisimova & Y. V. Morkovina

  4. Zakusov Institute of Pharmacology, ul. Baltiyskaya 8, Moscow, 125315, Russia

    G. I. Kovalev & I. A. Zimin

Authors
  1. A. A. Spasov
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  2. D. S. Yakovlev
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  3. D. V. Maltsev
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  4. O. N. Zhukovskaya
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  5. V. A. Anisimova
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  6. G. I. Kovalev
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  7. I. A. Zimin
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  8. Y. V. Morkovina
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Corresponding author

Correspondence to D. S. Yakovlev.

Additional information

Original Russian Text © A.A. Spasov, D.S. Yakovlev, D.V. Maltsev, O.N. Zhukovskaya, V.A. Anisimova, G.I. Kovalev, I.A. Zimin, Y.V. Morkovina, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 4, pp. 440–447.

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Spasov, A.A., Yakovlev, D.S., Maltsev, D.V. et al. The derivatives of imidazo[1,2-a]benzimidazole as 5-HT2A receptor antagonists. Russ J Bioorg Chem 42, 397–403 (2016). https://doi.org/10.1134/S1068162016040178

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  • DOI: https://doi.org/10.1134/S1068162016040178

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