Abstract
IN 1938, Holtz et al.1 reported that dopamine, which is pressor in the cat, was converted to a depressor substance after incubation with monoamine oxidase (MAO), for example, extracts of guinea pig kidneys. These authors suggested that the depressor agent might be dihydroxyphenyl acetic aldehyde, the primary deamination product of dopamine, since the addition of semicarbazide prevented the formation of the depressor substance.
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References
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HOLTZ, P., STOCK, K. & WESTERMANN, E. Formation of Tetrahydropapaveroline from Dopamine in vitro. Nature 203, 656–658 (1964). https://doi.org/10.1038/203656b0
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DOI: https://doi.org/10.1038/203656b0
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