Abstract
IN previous papers it was shown that atractyloside, a glycoside (formerly called K-atractylate) extracted from the rhizome of Atractylis gummifera, the aglycone of which contains the perhydrophenanthrene nucleus1, inhibits the uptake of oxygen by rat-liver mitochondria also at very low concentrations (0.0000036 M) and with a marked decrease of the P/O ratio2.
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Ajello, T., Piozzi, F., Quilico, A., and Sprio, V., Lincei-Rend. Sci. fis. mat. e nat., 28, 545 (1960); La Chimica e l'Industria, 42, 876 (1960).
Santi, R., Nature, 182, 257 (1958). Bruni, A., Bistocchi, M., and Contessa, A. R., Archivio Ital. Sci. Farmacol., Serie III, 10, 86 (1960).
Bruni, A., Bistocchi, M., and Contessa, A. R., Archivio Ital. Sci. Farmacol., Serie III, 10, 115 (1960).
Bistocchi, M., and Millo, A., Revista Espanola de Fisiologia, 16, Supp. 2, 259 (1960).
Borst, P., and Slater, E. C., Nature, 184, 1396 (1959).
Slater, E. C., Nature, 172, 975 (1953).
Borst, P., and Slater, E. C., Nature, 185, 537 (1960).
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BRUNI, A., CONTESSA, A. Inhibition of Phosphorylation by Atractyloside. Nature 191, 818–819 (1961). https://doi.org/10.1038/191818a0
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DOI: https://doi.org/10.1038/191818a0
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