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Glucokinase Activators Based on N-Aryl-N′-Pyridin-2-Ylurea Derivatives

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Pharmaceutical Chemistry Journal Aims and scope

A series of previously undescribed N-aryl-N′-pyridin-2-ylureas were prepared via the reaction of 2-aminopyridines with benzoyl azides and tested in vitro as activators of glucokinase. Statistically significant reductions of glucose levels as compared with controls were demonstrated for several compounds.

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Authors and Affiliations

  1. N. P. Ogarev National Research Mordovia State University, Saransk, Mordovia, 430005, Russia

    A. V. Semenov, I. V. Tarasova, V. S. Khramov, E. V. Semenova, V. I. Inchina & S. S. Vakaeva

Authors
  1. A. V. Semenov
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  2. I. V. Tarasova
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  3. V. S. Khramov
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  4. E. V. Semenova
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  5. V. I. Inchina
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  6. S. S. Vakaeva
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Corresponding author

Correspondence to A. V. Semenov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 21 – 24, March, 2018.

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Semenov, A.V., Tarasova, I.V., Khramov, V.S. et al. Glucokinase Activators Based on N-Aryl-N′-Pyridin-2-Ylurea Derivatives. Pharm Chem J 52, 209–212 (2018). https://doi.org/10.1007/s11094-018-1792-7

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  • DOI: https://doi.org/10.1007/s11094-018-1792-7

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