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Presynaptic Nature of Neuromuscular Depression in the Frog

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Abstract

WHEN a number of successive nerve impulses arrive at a curarized neuromuscular junction, the induced end-plate potentials show a gradual decrease in size (Wedensky-inhibition, or junctional fatigue). Two different mechanisms, though not exclusive of each other, are conceivable.

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Authors and Affiliations

  1. Department of Pharmacology, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    M. OTSUKA & M. ENDO

Authors
  1. M. OTSUKA
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  2. M. ENDO
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OTSUKA, M., ENDO, M. Presynaptic Nature of Neuromuscular Depression in the Frog. Nature 188, 501–502 (1960). https://doi.org/10.1038/188501a0

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