Skip to main content
SpringerLink
Log in

Lack of Direct Effect of Erythropoietin on Human Erythroid Cells in vitro

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE existence in the plasma and urine of anæmic patients and animals, of a substance which is capable of increasing the rate of production of red cells in normal recipients is now an undisputed fact. However, the mechanism by which this substance exerts its stimulatory effect is still obscure. Two mechanisms for its action can be postulated. A direct action of the hormone on erythroid cells to stimulate rate of cell division as well as rate of differentiation, that is to say, hæmoglobinization, would increase the rate of turnover of marrow. Alternatively the hormone could accelerate the rate of differentiation of stem cells into the erythron to expand the volume of active marrow without affecting the rate of turnover.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lajtha, L. G., J. Clin. Pathol., 5, 67 (1952). Lajtha, L. G., J. Phot. Sci., 2, 130 (1954). Lajtha, L. G., Oliver, R., Kumatori, T., and Ellis, F., Rad. Res., 8, 1 (1958).

    Article  CAS  Google Scholar 

  2. Hodgson, G., Perreta, M., Yudilevich, D., and Eskuche, I., Proc. Soc. Exper. Biol. and Med., 99, 137 (1958).

    Article  CAS  Google Scholar 

  3. Schroeder, L. R., Gurney, C. W., and Wackman, N., Nature, 181, 1537 (1958).

    Article  ADS  CAS  Google Scholar 

  4. Gordon, A. S., Proc. Conf. on Fundamental Problems and Techniques for Study of Kinetics of Cellular Proliferation, Salt Lake City, Utah. Jan. 19–21, 1959. (In the press.)

  5. Alpen, E. L., and Cranmore, D. Ibid.

Download references

Author information

Authors and Affiliations

  1. Radiobiology Laboratory, Department of Radiotherapy, University of Oxford,

    EDWARD L. ALPEN & L. G. LAJTHA

  2. Donner Laboratory, University of California, Berkeley, California

    DONALD C. VAN DYKE

Authors
  1. EDWARD L. ALPEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. G. LAJTHA
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. DONALD C. VAN DYKE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

ALPEN, E., LAJTHA, L. & VAN DYKE, D. Lack of Direct Effect of Erythropoietin on Human Erythroid Cells in vitro . Nature 184, 1228–1229 (1959). https://doi.org/10.1038/1841228a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1841228a0

  • Springer Nature Limited

This article is cited by

Search

Navigation