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Effect of Erythropoietin on Mononuclear Cells of the Bone Marrow and Spleen

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We studied the effect of preconditioning of human bone marrow mononuclear cells with erythropoietin on the immunophenotype of immunocompetent cells and paracrine activity of mouse splenocytes. The expression of erythropoietin receptors on immunocompetent human bone marrow cells was shown to change after a short-term (60 min) exposure to erythropoietin. The number of T helpers carrying erythropoietin receptors decreased and the number of T suppressors, B lymphocytes, and monocytes carrying erythropoietin receptors increased. The presence of 30% conditioned medium from human bone marrow mononuclear cells or 33.4 U/ml of erythropoietin reduced apoptosis/necrosis, increased intracellular activity of NADPH-dependent oxidoreductases of splenocytes, and did not affect oxidative phosphorylation (did not enhance lactate production and glucose uptake by cells).

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. P. Lykov, M. A. Surovtseva, N. A. Bondarenko & I. I. Kim

  2. Novosibirsk Research Institute of Tuberculosis, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    A. P. Lykov & Ya. Sh. Schwartz

Authors
  1. A. P. Lykov
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  2. M. A. Surovtseva
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  3. N. A. Bondarenko
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  4. I. I. Kim
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  5. Ya. Sh. Schwartz
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  6. O. V. Poveshchenko
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Correspondence to A. P. Lykov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 5, pp. 602-605, May, 2022

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Lykov, A.P., Surovtseva, M.A., Bondarenko, N.A. et al. Effect of Erythropoietin on Mononuclear Cells of the Bone Marrow and Spleen. Bull Exp Biol Med 173, 633–635 (2022). https://doi.org/10.1007/s10517-022-05602-3

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  • DOI: https://doi.org/10.1007/s10517-022-05602-3

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