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C12-Hydroxylation of Digitoxin

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Abstract

USING paper chromatographic methods it has been shown that, following digitoxin administration to rats, the urine contains small amounts of unchanged digitoxin together with larger quantities of two cardioactive metabolites previously designated metabolites C and G 1,2. Human urine collected for 12 hr. from normal adults after an oral dose of 1 mgm. of digitoxin has now been found to contain some unchanged digitoxin as well as apparently larger quantities of two metabolites. The two metabolites when eluted from paper and rechromatographed using two systems of paper chromatography could not be separated from metabolites C and G.

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Authors and Affiliations

  1. Department of Pharmacology, University of Sydney, Australia

    B. T. BROWN & S. E. WRIGHT

  2. Department of Pharmacology, University of Chicago,

    G. T. OKITA

Authors
  1. B. T. BROWN
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  2. S. E. WRIGHT
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  3. G. T. OKITA
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BROWN, B., WRIGHT, S. & OKITA, G. C12-Hydroxylation of Digitoxin. Nature 180, 607–608 (1957). https://doi.org/10.1038/180607a0

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  • DOI: https://doi.org/10.1038/180607a0

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