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Metabolism of Nicotinic Acid by Infants

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Abstract

THE recent work of Knox and Grossman1 has shown the existence of a new metabolite of nicotinic acid. They produced evidence that N-methylnicotinamide was oxidized by enzymes in the liver of the rabbit to N-methyl-2-pyridone-5-carboxylamide, and isolated that compound from the urine of human subjects who had been given daily doses of 0·6–0·9 gm. nicotinamide.

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References

  1. Knox, W. E., and Grossman, W. I., J. Biol. Chem., 166, 391 (1946); 168, 363 (1947).

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  2. Holman, W. I. M. (to be published).

  3. Hamil, B. M., Coryell, M., Roderuck, C., Kaucher, M., Moyer, E. Z., Harris, M. E., and Williams, H. H., Amer. J. Dis. Children, 74, 434 (1947).

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Authors and Affiliations

  1. Department of Experimental Medicine, B.A.O.R., Cambridge and Wuppertal

    R. F. A. DEAN & W. I. M. HOLMAN

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  1. R. F. A. DEAN
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  2. W. I. M. HOLMAN
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DEAN, R., HOLMAN, W. Metabolism of Nicotinic Acid by Infants. Nature 163, 97 (1949). https://doi.org/10.1038/163097a0

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