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Effect of Thiourea on the Development of the Amphibian

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Abstract

IT has been shown recently that certain of the sulphonamides and thiourea act as goitrogenic agents in the rat1,2,3. These substances have been found also to lower the basal metabolic rate in normal animals4,5 and to alleviate the symptoms of hyperthyroidism in humans6,7 by inhibiting the production of thyroid hormone, Since the frog larva is one of the most sensitive indicators of the presence or absence of thyroid material, it became of interest to test the effects of such compounds on the development of the tadpole.

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Authors and Affiliations

  1. Department of Biology, Washington Square College of Arts and Science, New York University, New York City

    ALBERT S. GOBDON & HARRY A. CHARIPPER

  2. Also of the Department of Chemistry, College of the City of New York, New York City

    E. D. GOLDSMITH

Authors
  1. ALBERT S. GOBDON
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  2. E. D. GOLDSMITH
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  3. HARRY A. CHARIPPER
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GOBDON, A., GOLDSMITH, E. & CHARIPPER, H. Effect of Thiourea on the Development of the Amphibian. Nature 152, 504–505 (1943). https://doi.org/10.1038/152504a0

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