Abstract
IT has recently been shown1 that 2: 6 dichlorophenol-indophenol, among other oxidising agents, inhibits reversibly glycolysis in muscle extract. It was of interest, therefore, to try the effect of this substance on tumour tissue. Though inhibition of glycolysis was not found, the effects on respiration were striking. The experiments were carried out with the Dixon-Keilin apparatus2 and the concentration of dichlorophenol-indophenol in the bicarbonate-containing medium was 1.3 × 103 M.
Similar content being viewed by others
References
Lipmann, Biochem. Z., 265, 133 ; 1933.
Biochem. J., 27, 86 ; 1933.
Waldschmidt-Leitz, McDonald, et al., Z. Physiol. Chem., 219, 115 ; 1933.
Harris, NATURE, 132, 27, July 1, 1933.
Harris, NATURE, 132, 605, Oct. 14, 1933.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ELLIOTT, K. Effect of 2:6-Dichlorophenol-Indophenol on Tumour and Kidney Respiration. Nature 134, 254 (1934). https://doi.org/10.1038/134254b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/134254b0
- Springer Nature Limited