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Studies on high-temperature amination reactions of aromatic chlorides using discrete Palladium-N-Heterocyclic Carbene (NHC) complexes and in situ palladium/imidazolium salt protocols

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Abstract

The palladium catalysed coupling of aryl chlorides and amines can be readily achieved with short reaction times when carried out at high temperatures under thermal or microwave conditions. These coupling protocols are successful using two co-ordinate palladium-N-heterocyclic carbene complexes, or imidazolium salt protocols.

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Authors and Affiliations

  1. The Chemistry Laboratory, School of Chemistry, Physics and Environmental Sciences, University of Sussex, Falmer, Brighton, U.K

    Andrew J. McCarroll, Lisa R. Titcomb, Alexandra K. de K. Lewis, F. Geoffrey N. Cloke, Alejandro Perez de Santana & Stephen Caddick

  2. Novartis Horsham Research Centre, Horsham, West Sussex, U.K

    David A. Sandham

  3. Technical University of Munich, Lichtenbergerstr. 4, D-85747, Munich, Germany

    Brian P. Davies & Wolfgang Hiller

Authors
  1. Andrew J. McCarroll
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  2. David A. Sandham
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  3. Lisa R. Titcomb
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  4. Alexandra K. de K. Lewis
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  5. F. Geoffrey N. Cloke
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  6. Brian P. Davies
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  7. Alejandro Perez de Santana
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  8. Wolfgang Hiller
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  9. Stephen Caddick
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Correspondence to Stephen Caddick.

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McCarroll, A.J., Sandham, D.A., Titcomb, L.R. et al. Studies on high-temperature amination reactions of aromatic chlorides using discrete Palladium-N-Heterocyclic Carbene (NHC) complexes and in situ palladium/imidazolium salt protocols. Mol Divers 7, 115–123 (2003). https://doi.org/10.1023/B:MODI.0000006863.14423.da

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  • DOI: https://doi.org/10.1023/B:MODI.0000006863.14423.da

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