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A new technique for labeling of Lipiodol with 188Re in the treatment of hepatic tumor

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Abstract

A new method for the synthesis of 188Re-Lipiodol without using a chelating agent and to evaluate the stability and biodistribution of the new agent in rats with hepatic tumors was attempted. Eighteen male Sprague -Dawley rats with liver tumors were sacrificed at 1, 24, and 48 hours (six rats at each time) after injection of approximately 7.4 MBq (0.2 mCi) of 188Re Lipiodol via the hepatic artery. Samples of tumor, liver and other organs were collected and tissue concentration (%ID/g) of the markers were calculated. Our data showed a high level of radioactivity in the hepatic tumors at every time of the study. The ratios of tumor to normal liver tissue concentration (T/N ratio) were 7.62 at 1 hour, 8.03 at 24 hours, and 7.70 at 48 hours. Except for the liver, kidneys and lungs, concentrations in other organs were low. The new method for labeling Lipiodol with 188Re is simple and has potential for the treatment of hepatic tumors

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References

  1. C. H. Park, J. H. Suh, H. S. Yoo, J. T. Lee, D. I. Kim, Clin. Nucl. Med., 11 (1986) 514.

    CAS  Google Scholar 

  2. M. T. Madsen, C. H. Park, M. L. Thakur, J. Nucl. Med., 29 (1988) 1038.

    CAS  Google Scholar 

  3. J. H. Risse, C. Ponath, H. Palmedo, C. Menzel, F. GrÜnwald, H. J. Biersack, Eur. J. Nucl. Med., 28 (2001) 914.

    Article  CAS  Google Scholar 

  4. S. J. Wang, W. Y. Lin, M. N. Chen, L. H. Shen, Z. T. Tsai, G. Ting, Eur. J. Nucl. Med., 22 (1995) 233.

    Article  CAS  Google Scholar 

  5. S. J. Wang, W. Y. Lin, M. N. Chen, L. H. Shen, Z. T. Tsai, G. Ting, J. Nucl. Med., 37 (1996) 332.

    CAS  Google Scholar 

  6. S. J. Wang, W. Y. Lin, M. N. Chen, B. T. Hsieh, Eur. J. Nucl. Med., 23 (1996) 13.

    Article  CAS  Google Scholar 

  7. S. J. Wang, W. Y. Lin, B. T. Hsieh, L. H. Shen, Z. T. Tsai, G. Ting, Appl. Radiation Isotopes, 47 (1996) 267.

    Article  CAS  Google Scholar 

  8. A. P. Callahan, D. E. Rice, F. F. Knapp Jr., J. Nucl. Med., 28 (1987) 657.

    Google Scholar 

  9. A. Kirschner, R. Ice, W. Beierwaltes, J. Nucl. Med., 16 (1975) 248.

    CAS  Google Scholar 

  10. Stabin MG, MIRDOSE: Personal computer software for internal dose assessment in nuclear medicine, J. Nucl. Med., 37 (1996) 538.

    CAS  Google Scholar 

  11. S. Maki, T. Konno, H. I. Maeda, Cancer, 56 (1985) 751.

    Article  CAS  Google Scholar 

  12. H. Ohishi, H. Uchida, H. Yoshimura et al., Radiology, 154 (1985) 25.

    CAS  Google Scholar 

  13. T. Konno, H. Maeda, K. Iwai et al., Eur. J. Cancer Clin. Oncol., 19 (1983) 1053.

    Article  CAS  Google Scholar 

  14. H. Nakamura, T. Hashimoto, H. Oi, S. Sawada, Radiology, 170 (1989) 783.

    CAS  Google Scholar 

  15. H. Kobayashi, Y. Hidaka, P. Tanque et al., Acta Radiol. Diagn., 27 (1986) 139.

    CAS  Google Scholar 

  16. J. L. Raoul, R. Duvauferrier, P. Bourguet et al., J. Radiol., 67 (1986) 797.

    CAS  Google Scholar 

  17. K. Iwai, H. Maeda, T. Konno, Cancer Res., 44 (1984) 2115.

    CAS  Google Scholar 

  18. H. Ngan, Br. J. Radiol., 63 (1990) 771.

    Article  CAS  Google Scholar 

  19. H. Kobayashi, H. Inoue, J. Shimada et al., Acta Radiol., 28 (1987) 275.

    CAS  Google Scholar 

  20. C. Park, S. I. Choi, H. Kim et al., Liver, 10 (1990) 72.

    CAS  Google Scholar 

  21. Z. Kan, K. Ivancev, I. Hagerstrand, V. Chuang, A. Lunderquist, Acta Radiol., 30 (1989) 419.

    Article  CAS  Google Scholar 

  22. K. Okuda, H. Musha, T. Yamasaki et al., Radiology, 122 (1977) 53.

    CAS  Google Scholar 

  23. A. G. Bledin, H. M. Kantarjian, E. E. Kim et al., AJR, 139 (1982) 711.

    CAS  Google Scholar 

  24. R. V. Mantravadi, D. G. Spigos, S. M. Karesh et al., Radiology, 148 (1983) 555.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Veterans General Hospital, Taichung and National Yang-Ming University, Taipei, Taiwan

    Shyh-Jen Wang & Wan-Yu Lin

  2. Institute of Nuclear Energy Research, Taiwan

    Tsai-Yueh Lo & Lie-Hang Shen

  3. National Taiwan University Taipei, Taiwan

    Ming-Ja Su

  4. Chungtai Institute of Health Sciences and Technology, Taichung, Taiwan

    Bor-Tsung Hsieh & Kai-Yuan Cheng

Authors
  1. Shyh-Jen Wang
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  2. Tsai-Yueh Lo
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  3. Bor-Tsung Hsieh
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  4. Kai-Yuan Cheng
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  5. Wan-Yu Lin
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  6. Lie-Hang Shen
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  7. Ming-Ja Su
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Wang, SJ., Lo, TY., Hsieh, BT. et al. A new technique for labeling of Lipiodol with 188Re in the treatment of hepatic tumor. Journal of Radioanalytical and Nuclear Chemistry 261, 189–193 (2004). https://doi.org/10.1023/B:JRNC.0000030955.44982.70

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  • DOI: https://doi.org/10.1023/B:JRNC.0000030955.44982.70

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