Abstract
Lipiodol functions as an embolizing agent for trans-arterial embolization and is used to deliver localized doses of chemotherapeutic drugs as well as ionizing radiation to cancerous tissue of the liver. Therefore, an attempt was made to prepare 68Ga-labeled lipiodol, which may have potential as a PET radiotracer for imaging of liver cancer. 68Ga-labeled lipiodol was prepared by a two-step procedure involving formation of highly lipophilic 68Ga-oxine complex followed by its dispersion in lipiodol. Preliminary biological evaluation in normal Wistar rats revealed satisfactory hepatic retention with insignificant uptake in any other major organ/tissue indicating promising potential of the agent.
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Acknowledgments
The authors are grateful to Dr. Vikram R. Lele, Director, Department of Nuclear Medicine, Jaslok Hospital and Research Centre, Mumbai for providing the 68Ge/68Ga generator used in the present study. The authors acknowledge Dr. K. L. Ramakumar, Director, Radiochemistry and Isotope group, Bhabha Atomic Research Centre (BARC), Mumbai for his support and encouragement. The help rendered by the staff members of Laboratory Animal House Facility of Radiation Biology and Health Sciences Divisions, BARC is also thankfully acknowledged.
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Ghosh, S., Das, T., Sarma, H.D. et al. Preparation and preliminary bioevaluation of 68Ga-oxine in lipiodol as a potential liver imaging agent. J Radioanal Nucl Chem 311, 263–268 (2017). https://doi.org/10.1007/s10967-016-4985-0
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DOI: https://doi.org/10.1007/s10967-016-4985-0