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JNK: A Key Modulator of Intracellular Signaling

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Abstract

JNK is a family of stress activated protein kinase enzymes that is under intense study. JNK family members are involved in diverse phenomena, but the focus of research has been until now involvement of JNK in apoptosis. A great number of JNK substrates indeed play major roles in cell death. Conversely, accumulating data support a key role of JNK substrates in cell survival and proliferation. Continuous progress is being made, while several important questions remain unanswered. Does JNK cause cancer or prevent it? This paper attempts to evaluate the role of JNK in cell physiology and describe the effects of intracellular signaling pathways that are mediated by JNK family members.

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REFERENCES

  1. Kyriakis, J. M., and Avruch, J. (2001) Physiol. Rev., 81, 807–869.

    PubMed  Google Scholar 

  2. Dunn, C., Wiltshire, C., MacLaren, A., and Gillespie, D. A. (2002) Cell Signal., 14, 585–593.

    Article  PubMed  Google Scholar 

  3. Ramet, M., Lanot, R., Zachary, D., and Manfruelli, P. (2002) Dev. Biol., 241, 145–156.

    Article  PubMed  Google Scholar 

  4. Kawasaki, M., Hisamoto, N., Iino, Y., Yamamoto, M., Ninomiya-Tsuji, J., and Matsumoto, K. (1999) EMBO J., 18, 3604–3615.

    Article  PubMed  Google Scholar 

  5. Gallo, K. A., and Johnson, G. L. (2002) Nat. Rev. Mol. Cell. Biol., 3, 663–672.

    Article  PubMed  Google Scholar 

  6. Davis, R. J. (2000) Cell, 103, 239–252.

    Article  PubMed  Google Scholar 

  7. Xie, X., Gu, Y., Fox, T., Coll, J. T., Fleming, M. A., Markland, W., Caron, P. R., Wilson, K. P., and Su, M. S. (1998) Structure, 6, 983–991.

    Article  PubMed  Google Scholar 

  8. Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S. S., Manning, A. M., and Anderson, D. W. (2001) Proc. Natl. Acad. Sci. USA, 98, 13681–13686.

    Article  PubMed  Google Scholar 

  9. Li, B., Tournier, C., Davis, R. J., and Flavell, R. A. (1999) EMBO J., 18, 420–432.

    Article  PubMed  Google Scholar 

  10. Li, J., Kartha, S., Iasvovskaia, S., Tan, A., Bhat, R. K., Manaligod, J. M., Page, K., Brasier, A. R., and Hershenson, M. B. (2002) Am. J. Physiol. Lung Cell. Mol. Physiol., 283, L690–699.

    Google Scholar 

  11. Wang, Y., Li, C., Wang, X., Zhang, J., and Chang, Z. (2002) Biochem. Biophys. Res. Commun., 296, 742–748.

    Article  PubMed  Google Scholar 

  12. Michiels, C., Minet, E., Michel, G., Mottet, D., Piret, J. P., and Raes, M. (2001) IUBMB Life, 52, 49–53.

    PubMed  Google Scholar 

  13. Gee, K., Lim, W., Ma, W., Nandan, D., Diaz-Mitoma, F., Kozlowski, M., and Kumar, A. (2002) J. Immunol., 169, 5660–5672.

    PubMed  Google Scholar 

  14. Chang, L., and Karin, M. (2001) Nature, 410, 37–40.

    Article  PubMed  Google Scholar 

  15. Cai, Y., Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., and Kitajima, S. (2000) Blood, 96, 2140–2148.

    PubMed  Google Scholar 

  16. Reboul, P., Pelletier, J. P., Tardif, G., Benderdour, M., Ranger, P., Bottaro, D. P., and Martel-Pelletier, J. (2001) Arthritis Rheum., 44, 73–84.

    Article  PubMed  Google Scholar 

  17. Shin, M., Yan, C., and Boyd, D. (2002) Biochim. Biophys. Acta, 1589, 311–316.

    Article  PubMed  Google Scholar 

  18. Zhang, X., Bedard, E. L., Potter, R., Zhong, R., Alam, J., Choi, A. M., and Lee, P. J. (2002) Am. J. Physiol. Lung Cell. Mol. Physiol., 283, L815-829.

    Google Scholar 

  19. Umenishi, F., and Schrier, R. W. (2003) J. Biol. Chem., 278, 15765–15770.

    Article  PubMed  Google Scholar 

  20. Chen, A., and Davis, B. H. (2000) Mol. Cell. Biol., 20, 2818–2826.

    Article  PubMed  Google Scholar 

  21. Hocevar, B. A., Brown, T. L., and Howe, P. H. (1999) EMBO J., 18, 1345–1356.

    Article  PubMed  Google Scholar 

  22. Schwabe, R. F., Bradham, C. A., Uehara, T., Hatano, E., Bennett, B. L., Schoonhoven, R., and Brenner, D. A. (2003) Hepatology, 37, 824–832.

    Article  PubMed  Google Scholar 

  23. Ellsworth, B. S., White, B. R., Burns, A. T., Cherrington, B. D., Otis, A. M., and Clay, C. M. (2003) Endocrinology, 144, 839–849.

    Article  PubMed  Google Scholar 

  24. Tamanini, A., Rolfini, R., Nicolis, E., Melotti, P., and Cabrini, G. (2003) Virology, 307, 228–242.

    Article  PubMed  Google Scholar 

  25. Ju, J. W., Kim, S. J., Jun, C. D., and Chun, J. S. (2002) IUBMB Life, 54, 293–299.

    PubMed  Google Scholar 

  26. Verrecchia, F., Tacheau, C., Wagner, E. F., and Mauviel, A. (2003) J. Biol. Chem., 278, 1585–1593.

    Article  PubMed  Google Scholar 

  27. Grosch, S., Tegeder, I., Schilling, K., Maier, T. J., Niederberger, E., and Geisslinger, G. (2003) FASEB J., 17, 1316–1318.

    PubMed  Google Scholar 

  28. Zoumpourlis, V., Papassava, P., Linardopoulos, S., Gillespie, D., Balmain, A., and Pintzas, A. (2000) Oncogene, 19, 4011–4021.

    Article  PubMed  Google Scholar 

  29. Buschmann, T., Potapova, O., Bar-Shira, A., Ivanov, V. N., Fuchs, S. Y., Henderson, S., Fried, V. A., Minamoto, T., Alarcon-Vargas, D., Pincus, M. R., Gaarde, W. A., Holbrook, N. J., Shiloh, Y., and Ronai, Z. (2001) Mol. Cell. Biol., 21, 2743–2754.

    Article  PubMed  Google Scholar 

  30. Noguchi, K., Kitanaka, C., Yamana, H., Kokubu, A., Mochizuki, T., and Kuchino, Y. (1999) J. Biol. Chem., 274, 32580–32587.

    Article  PubMed  Google Scholar 

  31. Prendergast, G. C. (1999) Oncogene, 18, 2967–2987.

    Article  PubMed  Google Scholar 

  32. Aplin, A. E., Hogan, B. P., Tomeu, J., and Juliano, R. L. (2002) J. Cell. Sci., 115, 2781–2790.

    PubMed  Google Scholar 

  33. Chow, C. W., Rincon, M., Cavanagh, J., Dickens, M., and Davis, R. J. (1997) Science, 278, 1638–1641.

    Article  PubMed  Google Scholar 

  34. Itoh, M., Adachi, M., Yasui, H., Takekawa, M., Tanaka, H., and Imai, K. (2002) Mol. Endocrinol., 16, 2382–2392.

    Article  PubMed  Google Scholar 

  35. Mizukami, Y., Yoshioka, K., Morimoto, S., and Yoshida, K. (1997) J. Biol. Chem., 272, 16657–16662.

    Article  PubMed  Google Scholar 

  36. Deng, X., Xiao, L., Lang, W., Gao, F., Ruvolo, P., and May, W. S., Jr. (2001) J. Biol. Chem., 276, 23681–23668.

    Article  PubMed  Google Scholar 

  37. Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y. N., Campbell, A., Sudha, T., Yuan, Z. M., Narula, J., Weichselbaum, R., Nalin, C., and Kufe, D. (2000) J. Biol. Chem., 275, 322–327.

    Article  PubMed  Google Scholar 

  38. Inoshita, S., Takeda, K., Hatai, T., Terada, Y., Sano, M., Hata, J., Umezawa, A., and Ichijo, H. (2002) J. Biol. Chem., 277, 43730–43734.

    Article  PubMed  Google Scholar 

  39. Ito, Y., Mishra, N. C., Yoshida, K., Kharbanda, S., Saxena, S., and Kufe, D. (2001) Cell Death Differ., 8, 794–800.

    Article  PubMed  Google Scholar 

  40. Donovan, N., Becker, E. B., Konishi, Y., and Bonni, A. (2002) J. Biol. Chem., 277, 40944–40949.

    Article  PubMed  Google Scholar 

  41. Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., and Davis, R. J. (1998) Science, 281, 1671–1674.

    Article  PubMed  Google Scholar 

  42. Lee, C. M., Onesime, D., Reddy, C. D., Dhanasekaran, N., and Reddy, E. P. (2002) Proc. Natl. Acad. Sci. USA, 99, 14189–14194.

    Article  PubMed  Google Scholar 

  43. Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., and Yamamoto, K. I. (1999) Mol. Cell. Biol., 19, 7539–7548.

    PubMed  Google Scholar 

  44. Barr, R. K., and Bogoyevitch, M. A. (2001) Int. J. Biochem. Cell. Biol., 33, 1047–1063.

    Article  PubMed  Google Scholar 

  45. Kuwabara, M., Takahashi, K., and Inanami, O. (2003) J. Radiat. Res. (Tokyo), 44, 203–209.

    Google Scholar 

  46. Sheikh, M. S., Antinore, M. J., Huang, Y., and Fornace, A. J., Jr. (1998) Oncogene, 17, 2555–2563.

    Article  PubMed  Google Scholar 

  47. Hung, C. C., Ichimura, T., Stevens, J. L., and Bonventre, J. V. (2003) J. Biol. Chem., 278, 29317–29326.

    Article  PubMed  Google Scholar 

  48. Parola, M., Robino, G., Marra, F., Pinzani, M., Bellomo, G., Leonarduzzi, G., Chiarugi, P., Camandola, S., Poli, G., Waeg, G., Gentilini, P., and Dianzani, M. U. (1998) J. Clin. Invest., 102, 1942–1950.

    PubMed  Google Scholar 

  49. Wang, T., Arifoglu, P., Ronai, Z., and Tew, K. D. (2001) J. Biol. Chem., 276, 20999–21003.

    Article  PubMed  Google Scholar 

  50. Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., Davis, R. J., and Ronai, Z. (1999) EMBO J., 18, 1321–1334.

    Article  PubMed  Google Scholar 

  51. Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., Wolf, C. R., and Park, B. K. (2003) J. Biol. Chem., 278, 22243–22249.

    Article  PubMed  Google Scholar 

  52. Cheng, W. H., Zheng, X., Quimby, F. R., Roneker, C. A., and Lei, X. G. (2003) Biochem. J., 370, 927–934.

    Article  PubMed  Google Scholar 

  53. Ventura, J.-J., Kennedy, N. J., Lamb, J. A., Flavell, R. A., and Davis, R. J. (2003) Mol. Cell. Biol., 23, 2871–2882.

    Article  PubMed  Google Scholar 

  54. Mandal, M., Olson, D. J., Sharma, T., Vadlamudi, R. K., and Kumar, R. (2001) Gastroenterology, 120, 71–78.

    PubMed  Google Scholar 

  55. Salehi, A. H., Xanthoudakis, S., and Barker, P. A. (2002) J. Biol. Chem., 277, 48043–48050.

    Article  PubMed  Google Scholar 

  56. Yang, Y. M., Bost, F., Charbono, W., Dean, N., McKay, R., Rhim, J. S., Depatie, C., and Mercola, D. (2003) Clin. Cancer Res., 9, 391–401.

    PubMed  Google Scholar 

  57. Hashimoto, Y., Tsuji, O., Niikura, T., Yamagishi, Y., Ishizaka, M., Kawasumi, M., Chiba, T., Kanekura, K., Yamada, M., Tsukamoto, E., Kouyama, K., Terashita, K., Aiso, S., Lin, A., and Nishimoto, I. (2003) J. Neurochem., 84, 864–877.

    Article  PubMed  Google Scholar 

  58. Zheng, C., Xiang, J., Hunter, T., and Lin, A. (1999) J. Biol. Chem., 274, 28966–28971.

    Article  PubMed  Google Scholar 

  59. Rennefahrt, U. E., Illert, B., Kerkhoff, E., Troppmair, J., and Rapp, U. R. (2002) J. Biol. Chem., 277, 29510–29518.

    Article  PubMed  Google Scholar 

  60. Chen, N., She, Q. B., Bode, A. M., and Dong, Z. (2002) Cancer Res., 62, 1300–1304.

    PubMed  Google Scholar 

  61. Yang, D. D., Conze, D., Whitmarsh, A. J., Barrett, T., Davis, R. J., Rincon, M., and Flavell, R. A. (1998) Immunity, 9, 575–585.

    Article  PubMed  Google Scholar 

  62. Verrecchia, F., Wagner, E. F., and Mauviel, A. (2002) EMBO Rep., 3, 1069–1074.

    Article  PubMed  Google Scholar 

  63. Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K., and Ichijo, H. (2002) Antioxid. Redox. Signal., 4, 415–425.

    Article  PubMed  Google Scholar 

  64. Potapova, O., Anisimov, S. V., Gorospe, M., Dougherty, R. H., Gaarde, W. A., Boheler, K. R., and Holbrook, N. J. (2002) Cancer Res., 62, 3257–3263.

    PubMed  Google Scholar 

  65. Manning, A. M., and Davis, R. J. (2003) Nat. Rev. Drug Discov., 2, 554–565.

    Article  PubMed  Google Scholar 

  66. Rahman, I. (2003) J. Biochem. Mol. Biol., 36, 95–109.

    PubMed  Google Scholar 

  67. Hadjigogos, K. (2003) Panminerva Med., 45, 7–13.

    PubMed  Google Scholar 

  68. Andreadis, A. A., Hazen, S. L., Comhair, S. A., and Erzurum, S. C. (2003) Free Rad. Biol. Med., 35, 213–225.

    Article  PubMed  Google Scholar 

  69. Lane, N. (2003) J. Theor. Biol., 225, 531–540.

    Article  PubMed  Google Scholar 

  70. Lo, Y. Y., Wong, J. M., and Cruz, T. F. (1996) J. Biol. Chem., 271, 15703–15707.

    Article  PubMed  Google Scholar 

  71. Pinkus, R., Weiner, L. M., and Daniel, V. (1996) J. Biol. Chem., 271, 13422–13429.

    Article  PubMed  Google Scholar 

  72. Han, Z., Boyle, D. L., Chang, L., Bennett, B., Karin, M., Yang, L., Manning, A. M., and Firestein, G. S. (2001) J. Clin. Invest., 108, 73–81.

    Article  PubMed  Google Scholar 

  73. Adcock, I. M., and Caramori, G. (2001) Immunol. Cell. Biol., 79, 376–384.

    Article  PubMed  Google Scholar 

  74. Rahman, A., Kefer, J., Bando, M., Niles, W. D., and Malik, A. B. (1998) Am. J. Physiol., 275, L533-544.

    Google Scholar 

  75. Zou, Y., Jung, K. J., Kim, J. W., Yu, B. P., and Chung, H. Y. (2003) FASEB J., 18, 320–322.

    PubMed  Google Scholar 

  76. Krunkosky, T. M., Martin, L. D., Fischer, B. M., Voynow, J. A., and Adler, K. B. (2003) Free Rad. Biol. Med., 35, 1158–1167.

    Article  PubMed  Google Scholar 

  77. Shetty, A., and Forbes, A. (2002) Am. J. Pharmacogenomics, 2, 215–221.

    PubMed  Google Scholar 

  78. Iles, K. E., and Forman, H. J. (2002) Immunol. Res., 26, 95–105.

    Article  PubMed  Google Scholar 

  79. Wilmer, W. A., Tan, L. C., Dickerson, J. A., Danne, M., and Rovin, B. H. (1997) J. Biol. Chem., 272, 10877–10881.

    Article  PubMed  Google Scholar 

  80. Iles, K. E., Dickinson, D. A., Watanabe, N., Iwamoto, T., and Forman, H. J. (2002) Free Rad. Biol. Med., 32, 1304–1313.

    Article  PubMed  Google Scholar 

  81. Adamson, G. M., and Billings, R. E. (1992) Arch. Biochem. Biophys., 294, 223–229.

    PubMed  Google Scholar 

  82. Inanami, O., Takahashi, K., Yoshito, A., and Kuwabara, M. (1999) Antioxid. Redox. Signal., 1, 113–121.

    PubMed  Google Scholar 

  83. Lee, L., Irani, K., and Finkel, T. (1998) Mol. Genet. Metab., 64, 19–24.

    Article  PubMed  Google Scholar 

  84. Inanami, O., Ohta, T., Ito, S., and Kuwabara, M. (1999) Antioxid. Redox. Signal., 1, 501–508.

    PubMed  Google Scholar 

  85. Ozaki, M., Deshpande, S. S., Angkeow, P., Suzuki, S., and Irani, K. (2000) J. Biol. Chem., 275, 35377–35383.

    Article  PubMed  Google Scholar 

  86. Meriane, M., Charrasse, S., Comunale, F., and Gauthier-Rouviere, C. (2002) Biol. Cell., 94, 535–543.

    Article  PubMed  Google Scholar 

  87. Abramov, A. Y., Canevari, L., and Duchen, M. R. (2003) J. Neurosci., 23, 5088–5095.

    PubMed  Google Scholar 

  88. Wilson, D. J., Fortner, K. A., Lynch, D. H., Mattingly, R. R., Macara, I. G., Posada, J. A., and Budd, R. C. (1996) Eur. J. Immunol., 26, 989–994.

    PubMed  Google Scholar 

  89. Gordeeva, A. V., Zvyagilskaya, R. A., and Labas, Y. A. (2003) Biochemistry (Moscow), 68, 1077–1080.

    Article  Google Scholar 

  90. Lee, K., and Esselman, W. J. (2002) Free Rad. Biol. Med., 33, 1121–1132.

    Article  PubMed  Google Scholar 

  91. Gu, Y., Xu, Y. C., Wu, R. F., Souza, R. F., Nwariaku, F. E., and Terada, L. S. (2002) Exp. Cell. Res., 272, 62–74.

    Article  PubMed  Google Scholar 

  92. Vlahopoulos, S., Boldogh, I., Casola, A., and Brasier, A. R. (1999) Blood, 94, 1878–1889.

    PubMed  Google Scholar 

  93. Zhou, L., Tan, A., Iasvovskaia, S., Li, J., Lin, A., and Hershenson, M. B. (2003) Am. J. Respir. Cell. Mol. Biol., 28, 762–769.

    Article  PubMed  Google Scholar 

  94. Davidson, B., Givant-Horwitz, V., Lazarovici, P., Risberg, B., Nesland, J. M., Trope, C. G., Schaefer, E., and Reich, R. (2003) Clin. Exp. Metastasis, 20, 621–631.

    Article  PubMed  Google Scholar 

  95. Woo, J. H., Lim, J. H., Kim, Y. H., Suh, S. I., Min, D. S., Chang, J. S., Lee, Y. H., Park, J. W., and Kwon, T. K. (2003) Oncogene, 23, 1845–1853.

    Article  Google Scholar 

  96. Katsanakis, K. D., Owen, C., and Zoumpourlis, V. (2002) Anticancer Res., 22, 755–759.

    PubMed  Google Scholar 

  97. Otth, C., Mendoza-Naranjo, A., Mujica, L., Zambrano, A., Concha, I. I., and Maccioni, R. B. (2003) Neuroreport, 14, 2403–2409.

    Article  PubMed  Google Scholar 

  98. Merienne, K., Helmlinger, D., Perkin, G. R., Devys, D., and Trottier, Y. (2003) J. Biol. Chem., 278, 16957–16967.

    Article  PubMed  Google Scholar 

  99. Royuela, M., Arenas, M. I., Bethencourt, F. R., Sanchez-Chapado, M., Fraile, B., and Paniagua, R. (2002) Hum. Pathol., 33, 299–306.

    Article  PubMed  Google Scholar 

  100. Collins, L. R., Minden, A., Karin, M., and Brown, J. H. (1996) J. Biol. Chem., 271, 17349–17353.

    Article  PubMed  Google Scholar 

  101. Pruitt, K., Pruitt, W. M., Bilter, G. K., Westwick, J. K., and Der, C. J. (2002) J. Biol. Chem., 277, 31808–31817.

    Article  PubMed  Google Scholar 

  102. Pulverer, B. J., Kyriakis, J. M., Avruch, J., Nikolakaki, E., and Woodgett, J. R. (1991) Nature, 353, 670–674.

    Article  PubMed  Google Scholar 

  103. Johnson, R., Spiegelman, B., Hanahan, D., and Wisdom, R. (1996) Mol. Cell. Biol., 16, 4504–4511.

    PubMed  Google Scholar 

  104. Behrens, A., Jochum, W., Sibilia, M., and Wagner, E. F. (2000) Oncogene, 19, 2657–2663.

    Article  PubMed  Google Scholar 

  105. Kennedy, N. J., Sluss, H. K., Jones, S. N., Bar-Sagi, D., Flavell, R. A., and Davis, R. J. (2003) Genes Dev., 17, 629–637.

    Article  PubMed  Google Scholar 

  106. Chen, N., Nomura, M., She, Q. B., Ma, W. Y., Bode, A. M., Wang, L., Flavell, R. A., and Dong, Z. (2001) Cancer Res., 61, 3908–3912.

    PubMed  Google Scholar 

  107. She, Q. B., Chen, N., Bode, A. M., Flavell, R. A., and Dong, Z. (2002) Cancer Res., 62, 1343–1348.

    PubMed  Google Scholar 

  108. Alfonso-De Matte, M. Y., Yang, H., Evans, M. S., Cheng, J. Q., and Kruk, P. A. (2002) Cancer Res., 62, 4575–4578.

    PubMed  Google Scholar 

  109. Pelengaris, S., Rudolph, B., and Littlewood, T. (2000) Curr. Opin. Genet. Dev., 10, 100–105.

    Article  PubMed  Google Scholar 

  110. Tan, Y., Demeter, M. R., Ruan, H., and Comb, M. J. (2000) J. Biol. Chem., 275, 25865–25869.

    Article  PubMed  Google Scholar 

  111. Crossthwaite, A. J., Hasan, S., and Williams, R. J. (2002) J. Neurochem., 80, 24–35.

    Article  PubMed  Google Scholar 

  112. Sakon, S., Xue, X., Takekawa, M., Sasazuki, T., Okazaki, T., Kojima, Y., Piao, J. H., Yagita, H., Okumura, K., Doi, T., and Nakano, H. (2003) EMBO J., 22, 3898–3909.

    Article  PubMed  Google Scholar 

  113. Deng, Y., Ren, X., Yang, L., Lin, Y., and Wu, X. (2003) Cell, 115, 61–70.

    Article  PubMed  Google Scholar 

  114. Theodosiou, A., and Ashworth, A. (2002) Oncogene, 21, 2387–2397.

    Article  PubMed  Google Scholar 

  115. Palacios, C., Collins, M. K., and Perkins, G. R. (2001) Curr. Biol., 11, 1439–1443.

    Article  PubMed  Google Scholar 

  116. Meriin, A. B., Yaglom, J. A., Gabai, V. L., Zon, L., Ganiatsas, S., Mosser, D. D., Zon, L., and Sherman, M. Y. (1999) Mol. Cell. Biol., 19, 2547–2555.

    PubMed  Google Scholar 

  117. Volloch, V., Gabai, V. L., Rits, S., Force, T., and Sherman, M. Y. (2000) Cell Stress Chaperones, 5, 139–147.

    Article  PubMed  Google Scholar 

  118. Park, H. S., Lee, J. S., Huh, S. H., Seo, J. S., and Choi, E. J. (2001) EMBO J., 20, 446–456.

    Article  PubMed  Google Scholar 

  119. Yaglom, J. A., Ekhterae, D., Gabai, V. L., and Sherman, M. Y. (2003) J. Biol. Chem., 278, 50483–50496.

    Article  PubMed  Google Scholar 

  120. Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H. P., and Ron, D. (2000) Science, 287, 664–666.

    Article  PubMed  Google Scholar 

  121. Chang, H. Y., Nishitoh, H., Yang, X., Ichijo, H., and Baltimore, D. (1998) Science, 281, 1860–1863.

    Article  PubMed  Google Scholar 

  122. Chen, L. Y., and Chen, J. D. (2003) Mol. Cell. Biol., 23, 7108–7121.

    Article  PubMed  Google Scholar 

  123. Michaelson, J. S., and Leder, P. (2003) J. Cell. Sci., 116, 345–352.

    Article  PubMed  Google Scholar 

  124. Kim, Y. Y., Park, B. J., Seo, G. J., Lim, J. Y., Lee, S. M., Kimm, K. C., Park, C., Kim, J., and Park, S. I. (2003) Biochem. Biophys. Res. Commun., 312, 426–433.

    Article  PubMed  Google Scholar 

  125. Chatterjee, M., and Wu, S. (2001) Mol. Cell. Biochem., 219, 21–27.

    Article  PubMed  Google Scholar 

  126. Zhan, Q., Jin, S., Ng, B., Plisket, J., Shangary, S., Rathi, A., Brown, K. D., and Baskaran, R. (2002) Oncogene, 21, 5335–5345.

    Article  PubMed  Google Scholar 

  127. Sordet, O., Khan, Q. A., Kohn, K. W., and Pommier, Y. (2003) Curr. Med. Chem. Anti-cancer Agents, 3, 271–290.

    Google Scholar 

  128. Kharbanda, S., Yuan, Z. M., Weichselbaum, R., and Kufe, D. (1998) Oncogene, 17, 3309–3318.

    Article  PubMed  Google Scholar 

  129. Lee, S. A., Dritschilo, A., and Jung, M. (1998) J. Biol. Chem., 273, 32889–32894.

    Article  PubMed  Google Scholar 

  130. Zhang, Y., Ma, W. Y., Kaji, A., Bode, A. M., and Dong, Z. (2002) J. Biol. Chem., 277, 3124–3131.

    Article  PubMed  Google Scholar 

  131. Aoki, H., Kang, P. M., Hampe, J., Yoshimura, K., Noma, T., Matsuzaki, M., and Izumo, S. (2002) J. Biol. Chem., 277, 10244–10250.

    Article  PubMed  Google Scholar 

  132. Watanabe, N., Iwamoto, T., Dickinson, D. A., Iles, K. E., and Forman, H. J. (2002) Arch. Biochem. Biophys., 405, 231–240.

    Article  PubMed  Google Scholar 

  133. Orr, W. C., and Sohal, R. S. (1994) Science, 263, 1128-1130.

  134. Wang, M. C., Bohmann, D., and Jasper, H. (2003) Dev. Cell., 5, 811–816.

    Article  PubMed  Google Scholar 

  135. Yoon, S. O., Yun, C. H., and Chung, A. S. (2002) Mech. Ageing Dev., 123, 1597–1604.

    Article  PubMed  Google Scholar 

  136. Krysan, K., and Lou, M. F. (2002) Invest. Ophthalmol. Vis. Sci., 43, 1876–1883.

    PubMed  Google Scholar 

  137. Shen, Y. H., Godlewski, J., Zhu, J., Sathyanarayana, P., Leaner, V., Birrer, M. J., Rana, A., and Tzivion, G. (2003) J. Biol. Chem., 278, 26715–26721.

    Article  PubMed  Google Scholar 

  138. Yu, C., Rahmani, M., Almenara, J., Sausville, E. A., Dent, P., and Grant, S. (2003) Oncogene, 23, 1364–1376.

    Article  Google Scholar 

  139. Yu, C., Subler, M., Rahmani, M., Reese, E., Krystal, G., Conrad, D., Dent, P., and Grant, S. (2003) Cancer Biol. Ther., 2, 544–551.

    PubMed  Google Scholar 

  140. Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., and Goldschmidt-Clermont, P. J. (1997) Science, 275, 1649-1652.

    Google Scholar 

  141. Burdon, R. H. (1995) Free Rad. Biol. Med., 18, 775–794.

    Article  PubMed  Google Scholar 

  142. Stone, J. R., and Collins, T. (2002) Endothelium, 9, 231–238.

    Article  PubMed  Google Scholar 

  143. Kwon, S. H., Pimentel, D. R., Remondino, A., Sawyer, D. B., and Colucci, W. S. (2003) J. Mol. Cell. Cardiol., 35, 615–621.

    Article  PubMed  Google Scholar 

  144. Cheng, W. H., Zheng, X., Quimby, F. R., Roneker, C. A., and Lei, X. G. (2003) Biochem. J., 370, 927–934.

    Article  PubMed  Google Scholar 

  145. Pollycove, M., and Feinendegen, L. E. (2003) Hum. Exp. Toxicol., 22, 290–306.

    Article  PubMed  Google Scholar 

  146. Van Campen, L. E., Murphy, W. J., Franks, J. R., Mathias, P. I., and Toraason, M. A. (2002) Hear Res., 164, 29–38.

    Article  PubMed  Google Scholar 

  147. Boldogh, I., Roy, G., Lee, M. S., Bacsi, A., Hazra, T. K., Bhakat, K. K., Das, G. C., and Mitra, S. (2003) Toxicology, 193, 137–152.

    Article  PubMed  Google Scholar 

  148. Vivo, C., Liu, W., and Broaddus, V. C. (2003) J. Biol. Chem., 278, 25461–25467.

    Article  PubMed  Google Scholar 

  149. Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., and Lin, A. (2001) Nature, 414, 313–317.

    Article  PubMed  Google Scholar 

  150. Reuther-Madrid, J. Y., Kashatus, D., Chen, S., Li, X., Westwick, J., Davis, R. J., Earp, H. S., Wang, C. Y., and Baldwin, A. S., Jr. (2002) Mol. Cell. Biol., 22, 8175–8183.

    Article  PubMed  Google Scholar 

  151. Lin, A. (2003) Bioessays, 25, 17–24.

    Article  PubMed  Google Scholar 

  152. Davies, K. J. (1999) IUBMB Life, 48, 41–47.

    PubMed  Google Scholar 

  153. Figueroa-Masot, X. A., Hetman, M., Higgins, M. J., Kokot, N., and Xia, Z. (2001) J. Neurosci., 21, 4657–4667.

    PubMed  Google Scholar 

  154. Shaulian, E., Schreiber, M., Piu, F., Beeche, M., Wagner, E. F., and Karin, M. (2000) Cell, 103, 897–907.

    Article  PubMed  Google Scholar 

  155. Mingo-Sion, A. M., Marietta, P. M., Koller, E., Wolf, D. M., and van den Berg, C. L. (2004) Oncogene, 23, 596–604.

    Article  PubMed  Google Scholar 

  156. Yoshida, S., Fukino, K., Harada, H., Nagai, H., Imoto, I., Inazawa, J., Takahashi, H., Teramoto, A., and Emi, M. (2001) J. Hum. Genet., 46, 182–187.

    Article  PubMed  Google Scholar 

  157. Nishitai, G., Shimizu, N., Negishi, T., Kishimoto, H., Nakagawa, K., Kitagawa, D., Watanabe, T., Momose, H., Ohata, S., Tanemura, S., Asaka, S., Kubota, J., Saito, R., Yoshida, H., Mak, T. W., Wada, T., Penninger, J. M., Azuma, N., Nishina, H., and Katada, T. (2004) J. Biol. Chem., 279, 1621–1626.

    Article  PubMed  Google Scholar 

  158. Habas, R., Dawid, I. B., and He, X. (2003) Genes Dev., 17, 295–309.

    Article  PubMed  Google Scholar 

  159. Lisovsky, M., Itoh, K., and Sokol, S. Y. (2002) Curr. Biol., 12, 53–58.

    Article  PubMed  Google Scholar 

  160. Dietrich, N., Thastrup, J., Holmberg, C., Gyrd-Hansen, M., Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jaattela, M., and Kallunki, T. (2003) Cell Death Differ., 11, 301–313.

    Article  Google Scholar 

  161. Kuan, C. Y., Yang, D. D., Roy, S. D. R., Davis, R. J., Rakic, P., and Flavell, R. A. (1999) Neuron, 22, 667–676.

    Article  PubMed  Google Scholar 

  162. Sabapathy, K., Jochum, W., Hochedlinger, K., Chang, L., Karin, M., and Wagner, E. F. (1999) Mech. Dev., 89, 115–124.

    Article  PubMed  Google Scholar 

  163. Faris, M., Ensoli, B., Stahl, N., Yancopoulos, G., Nguyen, A., Wang, S., and Nel, A. E. (1996) AIDS, 10, 369–378.

    PubMed  Google Scholar 

  164. Pessah, M., Prunier, C., Marais, J., Ferrand, N., Mazars, A., Lallemand, F., Gauthier, J. M., and Atfi, A. (2001) Proc. Natl. Acad. Sci. USA, 98, 6198–6203.

    Article  PubMed  Google Scholar 

  165. Sepulveda, J. L., Vlahopoulos, S., Iyer, D., Belaguli, N., and Schwartz, R. J. (2002) J. Biol. Chem., 277, 25775–25782.

    Article  PubMed  Google Scholar 

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Vlahopoulos, S., Zoumpourlis, V.C. JNK: A Key Modulator of Intracellular Signaling. Biochemistry (Moscow) 69, 844–854 (2004). https://doi.org/10.1023/B:BIRY.0000040215.02460.45

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