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CK2: A Global Regulator of Cell Death

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Protein Kinase CK2 Cellular Function in Normal and Disease States

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 12))

Abstract

Protein kinase CK2 has emerged as a major signal involved in diverse cellular functions of health and disease. The nature of its broad of range of functions is underscored by the large number of potential substrates of CK2 present in various locales in the cell. CK2 has gained much attention for its role in cancer biology, which is attributed to its functions both in cell growth and proliferation as well as in the regulation of cell death. Indeed, it appears that CK2 impact on cell death may be one of its most important functions, especially in the context of cancer biology where both cell proliferation and cell death are dysregulated and elevated CK2 in cancer would have an effect on both of these activities. Just as CK2 has been proposed to have a global role in cell growth-related activities, it appears that it may have an analogous global role in the suppression of apoptosis when it is elevated and induce cell death when it is downregulated. In this review, we have highlighted the current status of CK2 involvement in the processes related to cell death with a focus on apoptosis. It is proposed that a newly identified mechanism of CK2 regulation of cell death relates to its impact on early intracellular dynamics of Ca2+ signaling which profoundly alter mitochondrial function and lead to cell death.

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Abbreviations

CK2:

The adopted acronym for previous name casein kinase

CK2α:

42 kDa catalytic subunit of CK2

CK2 α′:

38 kDa catalytic subunit of CK2

CK2β:

28 kDa regulatory subunit of CK2

DR:

Death receptor

ER:

Endoplasmic reticulum

IAPs:

Inhibitor of apoptosis proteins (including cIAP1, cIAP2, XIAP, and survivin)

MNA:

1,8-Dihydroxy-4-nitro-anthracene-9,10-dione

OGN:

Oligonucleotides

NM:

Nuclear matrix

RIP1:

Receptor-interacting protein-1

ROS:

Reactive oxygen species

TBB:

4,5,6,7-Tetrabrombenzotriazole

TBCA:

Tetrabromocinnamic acid

TNFα:

Tumor necrosis factor α

TRADD:

TNF receptor type I-associated death domain protein

TRAF2:

TNF receptor-associated factor-2

TRAIL/Apo2-L:

Tumor necrosis factor-related apoptosis-inducing ligand

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Acknowledgments

The original work in the authors’ laboratory was supported in part by the US Department of Veterans Affairs Merit Review Program, grant number I01BX001731 (K.A.), Department of Health and Human Services, and National Cancer Institute, grant numbers R01CA150182, R01CA15062 (K.A.), and R21CA158730 (B.T.K.). One of us (K.A.) would like to dedicate this work to the memory of AHU and GS.

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Authors and Affiliations

  1. Cellular and Molecular Biochemistry Research Laboratory (151), Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, 55417, USA

    Janeen H. Trembley, Fatima Qaiser & Betsy T. Kren

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA

    Janeen H. Trembley & Betsy T. Kren

  3. Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA

    Janeen H. Trembley & Betsy T. Kren

  4. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA

    Fatima Qaiser

  5. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, MN, USA

    Khalil Ahmed

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  1. Janeen H. Trembley
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  3. Betsy T. Kren
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  4. Khalil Ahmed
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Correspondence to Khalil Ahmed .

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Editors and Affiliations

  1. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, Minnesota, USA

    Khalil Ahmed

  2. Dept of Biochemistry & Molecular Biology, University of Southern Denmark, Odense, Denmark

    Olaf-Georg Issinger

  3. Department of Molecular Biology, The John Paul II Catholic U. of Lublin Institute of Biotechnology, Lublin, Poland

    Ryszard Szyszka

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Trembley, J.H., Qaiser, F., Kren, B.T., Ahmed, K. (2015). CK2: A Global Regulator of Cell Death. In: Ahmed, K., Issinger, OG., Szyszka, R. (eds) Protein Kinase CK2 Cellular Function in Normal and Disease States. Advances in Biochemistry in Health and Disease, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-14544-0_10

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