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Effects of Phosphoinositide Cycle Modifiers on Apoptosis of Peritoneal Macrophages

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Abstract

Hydrogen peroxide stimulates apoptosis of zymosan-activated rat peritoneal macrophages. Phosphoinositide cycle modifiers enhance the proapoptotic effect of H2O2 in a concentration of 1 mM and necrosis-stimulating effect of H2O2 in a concentration of 10 mM. Disorders in phosphoinositide metabolism and impaired reaction of the cell to proinflammatory agents are the cause of programmed cell death. Rejection of defective cells can be realized via variation of H2O2 concentration.

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Authors and Affiliations

  1. N. P. Ogarev Mordovian State University, Saransk

    O. N. Aksenova, V. A. Trofimov & T. N. Lychkina

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  1. O. N. Aksenova
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  2. V. A. Trofimov
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  3. T. N. Lychkina
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Aksenova, O.N., Trofimov, V.A. & Lychkina, T.N. Effects of Phosphoinositide Cycle Modifiers on Apoptosis of Peritoneal Macrophages. Bulletin of Experimental Biology and Medicine 137, 575–577 (2004). https://doi.org/10.1023/B:BEBM.0000042716.14439.5a

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042716.14439.5a

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