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Phospholipase A2 Inhibitors Modulate the Effect of Trifluoperazine on the Intracellular Ca2+ Concentration in Macrophages

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Using Fura-2AM microfluorimetry, it was shown for the first time that phospholipase A2 inhibitors 4-bromophenacyl bromide and glucocorticosteroids prednisolone and dexamethasone attenuate Ca2+ responses induced by neuroleptic trifluoperazine in macrophages. The results suggest the involvement of phospholipase A2 and arachidonic acid metabolism cascade in the effect of trifluoperazine on intracellular Ca2+ concentration in macrophages.

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References

  1. Dilsaver, S.C., Amer. Fam. Phys., 1993, vol. 47, pp. 199–204.

    CAS  Google Scholar 

  2. Sudeshna, G. and Parimal, K., Eur. J. Pharmacol., 2010, vol. 648, pp. 6–14.

    Article  CAS  PubMed  Google Scholar 

  3. Hadjimitova, V., Bakalova, R., Traykov, T., et al., Cell Biol. Toxicol., 2003, vol. 19, pp. 3–12.

    Article  CAS  PubMed  Google Scholar 

  4. Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A., et al., in Sb. Retseptory i vnutrikletochnaya signalizatsiya (Receptors and Intracellular Signaling: Collected Papers), 2017, pp. 188–192.

    Google Scholar 

  5. Oruch, R., Lund, A., Pryme, I.F., et al., J. Chem. Biol., 2010, vol. 3, pp. 67–88.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Jaszczyszyn, A., Gasiorowski, K., Swiatek, P., et al., Pharmacol. Rep., 2012, vol. 64, pp. 16–23.

    Article  CAS  PubMed  Google Scholar 

  7. Walenga, R.W., Opas, E.E., and Feinstein, M.B., J. Biol. Chem., 1981, vol. 256, pp. 12523–12528.

    CAS  PubMed  Google Scholar 

  8. Irvine, R.F., Biochem. J., 1982, vol. 204, pp. 3–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gewert, K. and Sundler, R., Biochem. J., 1995, vol. 307, pp. 499–504.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A., et al., Tsitologiya, 2015, vol. 57, no.7. S. 518–525.

    CAS  Google Scholar 

  11. Grynkiewicz, G., Poenie, M., and Tsien, R.Y., J. Biol. Chem., 1985, vol. 260, pp. 3440–3450.

    CAS  PubMed  Google Scholar 

  12. Xie, Q., Zhang, Y., Zhai, C., et al., J. Biol. Chem., 2002, vol. 277, pp. 16559–16566.

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, 199034, Russia

    Z. I. Krutetskaya, L. S. Milenina, A. A. Naumova, S. N. Butov, V. G. Antonov & A. D. Nozdrachev

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  1. Z. I. Krutetskaya
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  2. L. S. Milenina
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  3. A. A. Naumova
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  4. S. N. Butov
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  5. V. G. Antonov
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  6. A. D. Nozdrachev
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Corresponding author

Correspondence to Z. I. Krutetskaya.

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Original Russian Text © Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, S.N. Butov, V.G. Antonov, A.D. Nozdrachev, 2018, published in Doklady Akademii Nauk, 2018, Vol. 478, No. 5, pp. 601–603.

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Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Phospholipase A2 Inhibitors Modulate the Effect of Trifluoperazine on the Intracellular Ca2+ Concentration in Macrophages. Dokl Biochem Biophys 478, 41–43 (2018). https://doi.org/10.1134/S1607672918010118

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  • DOI: https://doi.org/10.1134/S1607672918010118

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