Abstract
Fusion of 2-methylindole with morphinals of substituted salicylaldehydes (in a ratio of 1 : 1) afforded 3-[(2-hydroxyaryl)morpholinomethyl]-2-methylindoles as normal products of the Mannich reaction. In some cases, the reactions with an excess of 2-methylindole resulted in unusual condensation accompanied by the replacement of the OH group by the morpholino group to form bis(2-methylindol-3-yl)(2-morpholinoaryl)methanes.
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Ukhin, L.Y., Belousova, L.V. & Khrustalev, V.N. Reactions of 2-methylindole with morpholinals of substituted salicylaldehydes. Russian Chemical Bulletin 52, 700–704 (2003). https://doi.org/10.1023/A:1023923226389
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DOI: https://doi.org/10.1023/A:1023923226389