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Enhancement of the Effect of Methotrexate on Collagen II Induced Arthritis in Mice by Nicotinamide

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Abstract

Treatment with a combination of 10 mg/kg i.p. methotrexate and 100 mg/kg i.p. nicotinamide inhibits the development of collagen II induced arthritis in male DBA/1 X B.10(4R) mice, as assessed by the arthritic index and whole blood chemiluminescence. The effect is much more pronounced than with either methotrexate or nicotinamide alone at the same concentrations. Determination of GOT and GPT levels in the blood revealed that the treatment causes no toxic side effects on the liver.

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Authors and Affiliations

  1. Deutsches Rheumaforschungszentrum Berlin, Hannoversche Straße 27, 10115, Berlin, Germany

    Hans Kröger, Annette Hauschild & Manuela Ohde

  2. Robert Koch-Institut, Nordufer 20, 13353, Berlin, Germany

    Wolfgang Thefeld & Dieter Krüger

  3. Bundesinstitut für gesundheitlichen Verbraucherschutz und, Veterinärmedizin, Diedersdorfer Weg 1, 12277, Berlin, Germany

    Karl Bache

  4. Warthestr., 12051, Berlin, Germany

    Wilhelm Ehrlich

Authors
  1. Hans Kröger
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  2. Annette Hauschild
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  3. Manuela Ohde
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  4. Wolfgang Thefeld
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  5. Dieter Krüger
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  6. Karl Bache
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  7. Wilhelm Ehrlich
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Kröger, H., Hauschild, A., Ohde, M. et al. Enhancement of the Effect of Methotrexate on Collagen II Induced Arthritis in Mice by Nicotinamide. Inflammation 22, 277–285 (1998). https://doi.org/10.1023/A:1022348132132

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