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Halonal is a Phenobarbital Inductor of the Monooxygenase System

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Abstract

Experiments on rats demonstrated induction of the hepatic monooxygenase system with halonal. The effects of halonal and phenobarbital on the contents of cytochrome P-450 and its isoform P-450b+e and on the rate of substrate metabolism were similar. This suggests that enzyme-inducing activity of halonal is determined by the effect of its major metabolite. It cannot be excluded that halonal molecules possess intrinsic enzyme-inducing activity.

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Authors and Affiliations

  1. Department of Pharmacology, Siberian State Medical University, Tomsk, Russia

    A. S. Saratikov, T. P. Novozheeva & R. R. Akhmedzhanov

Authors
  1. A. S. Saratikov
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  2. T. P. Novozheeva
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  3. R. R. Akhmedzhanov
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Saratikov, A.S., Novozheeva, T.P. & Akhmedzhanov, R.R. Halonal is a Phenobarbital Inductor of the Monooxygenase System. Bulletin of Experimental Biology and Medicine 134, 264–266 (2002). https://doi.org/10.1023/A:1021559602469

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  • DOI: https://doi.org/10.1023/A:1021559602469

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