Abstract
Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis of apomorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy of cell preparations from 8- and lower from 16-17-day-old embryos. These data correlated with histomorphological findigs, in particular, with the size of grafts, glial reaction, and the number of dopaminergic neurons in the grafts.
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Chekhonin, V.P., Lebedev, S.V., Dmitrieva, T.B. et al. Comparison of the Efficacy of Cell Preparations from Embryonic Ventral Mesencephalon of Various Prenatal Age Transplanted Intrastriatally to Rats with 6-OHDA-Induced Parkinsonism. Bulletin of Experimental Biology and Medicine 133, 609–613 (2002). https://doi.org/10.1023/A:1020258531077
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DOI: https://doi.org/10.1023/A:1020258531077