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Stereotactic Surgery in Rats

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Experimental Neurosurgery in Animal Models

Part of the book series: Neuromethods ((NM,volume 116))

Abstract

Animal models represent the final step to complete preclinical investigations. Here, we describe in detail the principles and procedures for the surgical, toxin-induced animal models for Parkinson’s disease (PD), and Huntington’s disease (HD). Using highly precise stereotactic intracerebral injections of toxins into the nigrostriatal pathway and basal ganglia, we are able to target specific neural circuits in different regions of the dopaminergic and GABAergic system. In addition, validated protocols for adult and neonatal cell transplantation to reconstruct the destructed neuronal circuits as models for neural repair are described.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Heinrich-Heine University Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany

    Jaroslaw Maciaczyk & Ulf D. Kahlert

  2. Department of Stereotactic and Functional Neurosurgery, University of Freiburg Medical Center - Neurocentre, Breisacher Str. 64, 79106, Freiburg, Germany

    Máté Döbrössy & Guido Nikkhah

Authors
  1. Jaroslaw Maciaczyk
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  2. Ulf D. Kahlert
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  3. Máté Döbrössy
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  4. Guido Nikkhah
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Corresponding author

Correspondence to Jaroslaw Maciaczyk .

Editor information

Editors and Affiliations

  1. Mossakowski Medical Research Centre, Department of Neurosurgery, Warsaw, Poland

    Miroslaw Janowski

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Maciaczyk, J., Kahlert, U.D., Döbrössy, M., Nikkhah, G. (2016). Stereotactic Surgery in Rats. In: Janowski, M. (eds) Experimental Neurosurgery in Animal Models. Neuromethods, vol 116. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3730-1_3

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  • DOI: https://doi.org/10.1007/978-1-4939-3730-1_3

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3728-8

  • Online ISBN: 978-1-4939-3730-1

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