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Synthesis of 5-Phenyl-7-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Syntheses are reported for a series of 2-alkylamino-6-phenyl-4-trifluoromethylpyridines. The reaction of 3-cyano-2-(hydroxyalkylamino)-6-phenyl-4-trifluoromethylpyridines with thionyl chloride gave the corresponding 2-(chloroalkylamino)pyridines, 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydro-imidazo[1,2-a]pyridines, and 9-cyano-6-phenyl-8-trifluoromethyl-2,3,4-trihydropyrido[1,2-a]-pyrimidines. X-ray diffraction structural analysis was used to study 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridine.

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REFERENCES

  1. E. Yu. Gudriniece, M. Yu. Lidak, M. V. Yure, G. V. Vladyko, S. N. Nikolaev, E. I. Boreko, and P. G. Rytik, USSR Inventor's Certificate No. 1769 515; Byul. Izobr., No. 10 (1992).

  2. E. Yu. Gudriniece, M. Y. Lidak, M. V. Yure, G. V. Vladyko, E. I. Boreko, and V. I. Botykov, USSR Inventor's Certificate No. 1704 417; Byul. Izobr., No. 1 (1992).

  3. A. V. Guttsait, S. V. Belyakov, A. F. Mishnev, Ya. Ya. Breidelis, and E. Yu. Gudriniece, Khim. Geterotsikl. Soedin., 1233 (1987).

  4. M. V. Yure, E. Yu. Gudriniece, M. V. Petrova, E. K. Rantsane, and E. B. Mazheika, Izv. Akad. Nauk LatvSSR, Ser. Khim., 439 (1990).

  5. O. Bremer, Liebigs Ann. Chem., 521, 286 (1936).

    Google Scholar 

  6. L. Cossey, R. L. N. Harris, J. L. Hupatz, and J. N. Phillips, Austr. J. Chem., 29, 1039 (1976).

    Google Scholar 

  7. E. Suloeva, M. Yure, and E. Gudriniece, Khim. Geterotsikl. Soedin., 1299 (1999).

  8. E. Suloeva, M. Yure, and E. Gudriniece, Khim. Geterotsikl. Soedin., 1011 (2000).

  9. A. F. Mishnev and S. V. Belyakov, Kristallografiya, 33, 835 (1988).

    Google Scholar 

  10. P. Gluzinskii, Ya. Kraevskii, A. Kemme, and A. Kemme, in: Abstracts of the Second All-Union Conference on Precision Studies of Crystal Structure[in Russian], Riga (1990), p. 30.

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Authors and Affiliations

  1. Riga Technical University, LV-1048, Riga, Latvia

    E. Suloeva, M. Yure, E. Gudriniece, M. Petrova & I. Kalnite

  2. Latvian Institute of Organic Synthesis, LV-1006, Riga, Latvia

    S. Belyakov

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  1. E. Suloeva
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  2. M. Yure
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  3. E. Gudriniece
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  4. S. Belyakov
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  5. M. Petrova
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  6. I. Kalnite
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Suloeva, E., Yure, M., Gudriniece, E. et al. Synthesis of 5-Phenyl-7-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridines. Chemistry of Heterocyclic Compounds 37, 329–337 (2001). https://doi.org/10.1023/A:1017511217288

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  • DOI: https://doi.org/10.1023/A:1017511217288

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