Abstract
Activity of A and B types of monoamine oxidase (MAO) has been investigated in the brain stem and brain hemispheres of mink males of five genotypes for coat color mutations: standard dark-brown (+/+); heterozygous for the semidominant mutation Black crystal(Cr/+); homozygous for the semidominant mutation Black cross, or “95% White” (S/S); heterozygous for the semidominant mutationShadow(S H/+); and homozygous for the semirecessive mutation hedlund white(h/h). The main changes in the activity of the A and B MAO types occur in the brain hemispheres. A reduced activity of MAO A has been recorded in the hemispheres of Black crystalminks (Cr/+) and an elevated activity, in the hemispheres of Shadow(S H/+) and 95% White(S/S). The activity of MAO B is reduced in the hemispheres of Black crystaland elevated in the hemispheres of hedlund white(h/h). An increased MAO A activity has also been recorded in the brain stem of Shadowminks (S H/+). It is suggested that genes controlling coat color have a pleiotropic effect on sexual behavior in males and the endocrine function of testicles mediated by a putative change in the metabolism of brain neurotransmitters, substrates of MAOs A and B.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Popova, N.K., Voitenko, N.N., Kulikov, A.V., et al., The Pleiotropic Effect of One-Locus (pp) and Two-Locus (aa Pp) Mutations of Mink Coat Color Genes on Serotonin Metabolism in the Brain, Genetika (Moscow), 1994, vol. 30, no. 11, pp. 1513-1515.
Popova, N.K., Nikulina, E.M., Voitenko, N.N., et al., Effect of a One-Locus Mutation in the Allele pp for Silver-Blue Color on the Brain Dopamine System in Mink, Genetika (Moscow), 1996, vol. 32, no. 3, pp. 452-454.
Trapezov, O.V., Changing the Defensive Reaction to Humans by Selection in American Mink Mustela vison Schreb., Genetika (Moscow), 1987, vol. 23, no. 6, pp. 1120-1127.
Trapezov, O.V., Prasolova, L.A., Kharlamova, A.V., et al., The Selection for Aggressiveness Enhanced the Hair Pigmentation in Mink, Proc. VI Int. Sci. Congr. in Fur Animal Production, Applied Science. Rep., Warsaw, 1996, vol. 29, pp. 39-43.
Trapezov, O.V., A Rise of New Color Phases in American Mink (Mustela vison Schreber) in the Course of Selection for Domestic Behavior, Scientifur, 1997, vol. 21, no. 1, pp. 41-47.
Kharlamova, A.V. and Trapezov, O.V., The Pleiotropic Effect of the Black crystal Mutation on Reproduction Traits in American Mink Mustela vison, Genetika (Moscow), 1999, vol. 35, no. 6, pp. 765-770.
Trapezov, O.V., Black crystal: A Novel Coat Color Mutant in the American Mink, J. Hered., 1997, vol. 88, no. 2, pp. 164-166.
Trapezov, O.V., Generation of New Coat Colors during Selection for Behavior in American Mink Mustela vison, Evolyutsionno-geneticheskie i genetiko-fiziologicheskie aspekty domestikatsii pushnykh zverei (Evolutionary-Genetic and Genetic-Physiological Aspects of Domestication of Fur-Bearing Animals), Trut, L.N., Osadchuk, L.V., and Borodin, P.M., Eds., Novosibirsk: Inst. Tsitol. Genet. SORAN, 1991, pp. 185-218.
Evsikov, V.I., Genetic Evolutionary Aspects of Problematic Fertility Homeostasis in Mammals (Exemplified by Mink), Genetika (Moscow), 1987, vol. 23, no. 6, pp. 988-1002.
Gulevich, R.G., Osadchuk, L.V., and Klochkov, D.V., Endocrine Function of the Gonads in Male Mink Mustela vison of Two Genotypes, Zh. Evol. Biokhim. Fiziol., 1984, vol. 20, no. 5, pp. 484-487.
Il'ina, E.D. and Kuznetsov, G.A., Osnovy genetiki i selektsii pushnykh zverei (Basics in Genetics and Breeding of Fur-Bearing Animals), Moscow: Kolos, 1969.
Gorkin, V.Z., Verevkina, I.V., Gridneva, L.I., et al., Methods for Studying the Activity and Specific Inhibition of Mitochondrial Monoamine Oxidases, Sovremennye metody v biokhimii (Modern Techniques in Biochemistry), Orekhovich, V.N., Ed., Moscow: Meditsyna, 1968, pp. 155-177.
Silakova, A.I., Trush, G.P., and Yavilyakova, A., A Micromethod for Quantifying Ammonia and Glutamine in Tissue Extracts Obtained with Trichloroacetic Acid, Vopr. Med. Khim., 1962, no. 8, pp. 538-545.
Voitenko, N.N. and Trapezov, O.V., Species-Specificity of Brain Monoamine Oxidases in Mink and Rat, Zh. Evol. Biokhim. Fiziol., 1999, vol. 35, no. 6, pp. 462-465.
Wahlund, L.O., Saaf, J., Ross, S.B., and Wetterberg, L., Activation of Monoamine Oxidase by High Molecular Weight Fraction of Human Plasma, Acta Physiol. Scand., 1984, vol. 120, pp. 337-341.
Isaac, L., Schoenbeck, R., Bacher, J., et al., Electroconvulsive Shock Increases Endogenous Monoamine Oxidase Inhibitor Activity in Brain and Cerebrospinal Fluid, Neurosci. Lett., 1986, vol. 66, pp. 257-262.
Zhu, Q.S., Chen, K., and Shih, J.C., Bidirectional Promoter to Human Monoamine Oxidase A (MAO A) Controlled by Transcription Factor Sp1, J. Neurosci., 1994, vol. 14, no. 12, pp. 7393-7403.
Ivanov, V., Stein, B., Bauman, I., et al., Interaction with the Intracellular Protozoan Parasite Theileria parva Induces Constitutively High Levels of NF-B in Bovine T Lymphocytes, Mol. Cell. Biol., 1989, vol. 9, no. 11, pp. 4677-4686.
Kitado, H. and Fan, H., Chromatin Structure of Recombinant Murine Leukemia Virus Proviral DNAs That Contain Tax-Responsive Sequences from Human T-Cell Lymphotropic Virus Type 11 in the Presence and Absence of Tax, J. Virol., 1989, vol. 63, no. 7, pp. 3072-3079.
Tagliamonte, A., Tagliamonte, P., Gessa, G.L., and Bordie, B.B., Compulsive Sexual Activity Induced by p-Chlorophenylalanine in Normal and Pinealectomized Male Rats, Science, 1969, vol. 166, pp. 1433-1435.
Naumenko, E.V., Serova, L.I., and Maslova, L.N., Involvement of Dopaminergic Receptors in Functional Activation of the Male Gonads, Probl. Endokrinol., 1975, vol. 21, no. 6, pp. 53-56.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Voitenko, N.N., Trapezov, O.V. Effect of Four Coat Color Mutations (Cr, S, SH, and h) on Brain Monoamine Oxidase in Mink. Russian Journal of Genetics 37, 519–522 (2001). https://doi.org/10.1023/A:1016666631573
Issue Date:
DOI: https://doi.org/10.1023/A:1016666631573