Abstract
Methods of calculating the area under the concentration–time curve and the associated standard error are proposed for studies in which each animal contributes one independent data point to a pool of data. This approach can be used for data analysis in bioequivalence studies employing tissue sampling compartments. Application of this method indicated that an azone-containing ophthalmic formulation of levobunolol did not produce better ocular bioavailability than a formulation containing no penetration enhancer.
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Tang-Liu, D.DS., Burke, P.J. The Effect of Azone on Ocular Levobunolol Absorption: Calculating the Area Under the Curve and Its Standard Error Using Tissue Sampling Compartments. Pharm Res 5, 238–241 (1988). https://doi.org/10.1023/A:1015997814379
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DOI: https://doi.org/10.1023/A:1015997814379