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Synthesis of 2"-bromo-8-methylspiro(4H-3,1-benzooxazine-4,1"-cyclopentan)-2(1H)-one and 2-amino-2"-bromo-8-methylspiro(4H-3,1-benzooxazine-4,1"-cyclopentane) from 6-(cyclopent-1-enyl)-2-methylaniline

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Abstract

The reaction of 6-(cyclopent-1-enyl)-N-ethoxycarbonyl-2-methylaniline with Br2 or its reaction with NH3 followed by the reaction with Br2 afforded 2"-bromo-8-methylspiro(4H-3,1-benzooxazine-4,1"-cyclopentan)-2(1H)-one and 2-amino-2"-bromo-8-methylspiro(4H-3,1-benzooxazine-4,1"-cyclopentane), respectively.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Research Center of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russian Federation

    R. R. Gataullin, I. S. Afon"kin, A. A. Fatykhov, L. V. Spirikhin & I. B. Abdrakhmanov

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  1. R. R. Gataullin
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  2. I. S. Afon"kin
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  3. A. A. Fatykhov
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  4. L. V. Spirikhin
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  5. I. B. Abdrakhmanov
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Gataullin, R.R., Afon"kin, I.S., Fatykhov, A.A. et al. Synthesis of 2"-bromo-8-methylspiro(4H-3,1-benzooxazine-4,1"-cyclopentan)-2(1H)-one and 2-amino-2"-bromo-8-methylspiro(4H-3,1-benzooxazine-4,1"-cyclopentane) from 6-(cyclopent-1-enyl)-2-methylaniline. Russian Chemical Bulletin 50, 2466–2467 (2001). https://doi.org/10.1023/A:1015020604764

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  • DOI: https://doi.org/10.1023/A:1015020604764

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