Skip to main content
SpringerLink
Log in

Biocompatibility of Modified Silica-Protein Composite Layers

  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

Biocomposite layers of silica and various bone-relevant proteins such as collagen, gelatine and commercial collagen hydrolysate can be obtained from coatings of silica sols mixed with proteins in water/dioxane. Investigations into the mechanical and cell proliferation properties for different sol parameters (pH, solvent), type and concentration of proteins, annealing and crosslinking of the biocomposite layers revealed that such coatings are highly biocompatible with excellent mechanical properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. Avnir, S. Braun, O. Lev, and M. Ottolenghi, Chem. Mater. 6, 1605 (1994).

    Google Scholar 

  2. B.C. Dave, B. Dunn, J.S. Valentine, and J.I. Zink, Anal. Chem. 66, 1120A (1994).

    Google Scholar 

  3. J. Livage, C.R. Acad. Sci. Paris 322, 417 (1996).

    Google Scholar 

  4. B. Dunn, J.M. Miller, B.C. Dave, J.S. Valentine, and J.I. Zink, Acta Metallurgica 46, 737 (1998).

    Google Scholar 

  5. P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura, and T. Tamamuro, J. Amer. Ceram. Soc. 75, 2094 (1992).

    Google Scholar 

  6. P. Li, X.r Ye, I. Kangasniemi, J.M.A. de Blieck-Hogervorst, C.P.A.T. Klein, and K. deGroot, J. Biomed. Mat. Res. 29, 325 (1995).

    Google Scholar 

  7. M.M. Pereira, E. Clarke, and L.L. Hench, J. Amer. Ceram. Soc. 78, 2463 (1995).

    Google Scholar 

  8. M.M. Pereira and L.L. Hench, J. Sol-Gel Sci. Techn. 7, 59 (1996).

    Google Scholar 

  9. L.L. Hench, Curr. Opin. in Solid State & Materials Science 2, 604 (1997).

    Google Scholar 

  10. L.L. Hench, D.L. Wheeler, and D.C. Greenspan, J. Sol-Gel Sci. Techn. 13, 245 (1998).

    Google Scholar 

  11. L. Addadi and S. Weiner, Angew. Chem. 104, 159 (1992).

    Google Scholar 

  12. S. Mann, J. Mater. Chem. 5, 935 (1995).

    Google Scholar 

  13. G.K. Hunter, Curr. Opin. in Solid State & Materials Science 1, 430 (1996).

    Google Scholar 

  14. T. Mosmann, J. Immunolog. Methods 65, 55 (1983).

    Google Scholar 

  15. H.J. Watzke and C. Dieschbourg, Adv. Colloid and Interface Sci. 50, 1 (1994).

    Google Scholar 

  16. ISO 10993: Biological evaluation of medical devices. Part 5: Test for cytotoxicity. International Organization for Standardization 1992.

Download references

Author information

Authors and Affiliations

  1. Feinchemie GmbH Sebnitz, Höhenweg 9, D-01855, Sebnitz, Germany

    Ingo Brasack

  2. Feinchemie GmbH Sebnitz, Höhenweg 9, D-01855, Sebnitz, Germany

    Horst Böttcher

  3. Institut f. Physiologische Chemie, TU Dresden, Karl-Marx-Str.3, D-01109, Dresden, Germany

    Ute Hempel

Authors
  1. Ingo Brasack
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Horst Böttcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ute Hempel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brasack, I., Böttcher, H. & Hempel, U. Biocompatibility of Modified Silica-Protein Composite Layers. Journal of Sol-Gel Science and Technology 19, 479–482 (2000). https://doi.org/10.1023/A:1008763900729

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1008763900729

Search

Navigation