Abstract
Diuretics, either as monotherapy or in combination with other drugs in the management of hypertension, have retarded the development of left ventricular hypertrophy and congestive heart failure in many patients. Diuretics also remain one of the most effective therapies in the treatment of congestive heart failure, when given with an ACE inhibitor and digoxin.
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Hebert P, Moser M, Mayer J, Hennekens C. Recent evidence on drug therapy of mild to moderate hypertension and decreased risk of coronary heart disease. Arch Intern Med 1993;153:578–581.
Data from NHLBI. Chart Book on Cardiovascular, Lung and Blood Diseases. May 1992.
The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991;325:293–302.
Moser M, Hebert P. Prevention of disease progression, left ventricular hypertrophy and congestive heart failure in the hypertension treatment trials. J Am Coll Cardiol, 1996, in press.
Oslo Study. Treatment of mild hypertension. A five-year controlled drug trial. Am J Med 1980;69:725–732.
U.S. Public Health Service Hospitals Cooperative Study Group. Treatment of mild hypertension. Results of a ten-year intervention trial. Circ Res 1977;40(Suppl 1):98–105.
European Working Party on High Blood Pressure in the Elderly. Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly. Lancet 1985;1:1349–1354.
Hypertension Detection and Follow-up Program Cooperative Group. Five-year findings of the Hypertension Detection and Follow-up Program. 1. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA 1979;242:2562–2571.
Materson BJ, Reda DJ, Cushman WC, et al. Single-drug therapy for hypertension in men: A comparison of six anti-hypertensive agents with placebo. Result of a Department of Veterans Affairs Cooperative Study. N Engl J Med 1993;328:914–921.
Neaton JD, Grimm RH, Prineas RJ, et al. for the Treatment of Mild Hypertension Study Research Group. Treatment of mild hypertension study: Final results. JAMA 1993;270:713–724.
Veterans Administration Cooperative Study Group on Anti-hypertensive Agents. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 90 through 114 mm Hg. JAMA 1970;213:1143–1152.
Veterans Administration Cooperative Study Group on Anti-hypertensive Agents. Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 1967;202:1028–1034.
The Australian Therapeutic Trial in Mild Hypertension. Lancet 1980;1:1261–1267.
SHEP Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991;265:3255–3264.
Dahlof B, Lindholm LH, Hansson L, Schersten B, Ekbom T, Wester PO. Morbidity and mortality in the Swedish Trial in Old Persons with Hypertension (STOP-Hypertension). Lancet 1991;338:1281–1285.
Coope J, Warrender TS. Randomized trial of treatment of hypertension in elderly patients in primary care. Br Med J 1986;293:1145–1151.
Hypertension-Stroke Cooperative Study Group. Effect of antihypertensive treatment on stroke recurrence. JAMA 1974;229:409–418.
Wolff FW, Lindeman RD. Effects of treatment in hypertension: Results of a controlled study. J Chronic Dis 1966;19:227–240.
Carter AB. Hypotensive therapy in stroke survivors. Lancet 1970;1:485.
MRC Working Party. Medical Research Council trial of treatment of mild hypertension: Principal results. Br Med J 1985;291:97–104.
MRC Working Party. Medical Research Council trial of treatment of hypertension in older adults: Principal results. Br Med. 1992;304:405–412.
Fifth Report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure (JNCV). Arch Intern Med 1993;153:154–183.
Fouad FM, Nakashima Y, Tarazi RC, Salcedo EE. Reversal of left ventricular hypertrophy in hypertensive patients treated with methyldopa. Am J Cardiol 1982;49:795–799.
Braunwald E. Pathophysiology of heart failure. In Braunwald E, ed. Heart Disease, a Textbook of Cardiovascular Medicine, 3rd ed. Philadelphia: W.B. Saunders, 1988:426–448.
Langbehn AF, Achhammer I, Bolke T. Acute hemodynamic effects of 20 mg torasemide and 20 mg furosemide given intravenously to patients with congestive heart failure. Prog Pharmacol Clin Pharmacol 1990;8:147–155.
Smith TW, Braunwald E, Kelly RA. The management of heart failure. In: Braunwald E, ed. Heart Disease, a Textbook of Cardiovascular Medicine, 4th ed. Philadelphia: W.B. Saunders, 1992:464–519.
Krack F. Acute and long-term effects of loop diuretics in heart failure. Drugs 1991;41(Suppl 3):60–68.
Pfeffer MA, Braunwald E, Moye LA, et al. for the SAVE investigators. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the Survival and Ventricular Enlargement trial. N Engl J Med 1992;327:669–677.
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Moser, M. Diuretics in the Prevention and Treatment of Congestestive Heart Failure. Cardiovasc Drugs Ther 11 (Suppl 1), 273–277 (1997). https://doi.org/10.1023/A:1007791814100
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DOI: https://doi.org/10.1023/A:1007791814100