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Antimicrobial Metal and Metal Oxide Nanoparticles in Bone Tissue Repair

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Abstract

After the implantation of dental implants or orthopedic device, there is a “race for the surface,” a competitive battle between bacteria and host cells for the occupation of the implant surface. Various antibacterial and antibiotic agents have been developed to assist host tissue cells in winning this battle. However, these agents come with drawbacks, such as the potential to generate antibiotic resistance. Metal and metal oxide nanoparticles (NPs) have demonstrated their versatility, functioning as effective antimicrobial coatings, and flexible biomaterials with both osteoconductive and osteoinductive characteristics. In this review article will focus on the basics of implant infection and biofilm formation, followed by a discussion of antibiotic resistance, which favors bacteria, and strategies to reduce antibiotic resistance. Metal and metal oxide NPs and their expanding role in dental and orthopedic therapeutics will be discussed comprehensively. The article will focus on the potential for using metal and metal oxide NPs that integrate antimicrobial properties with osteoinductive/osteoconductive characteristics. Current advances and developments in the application of metal NPs will occupy the bulk of this review, which will conclude with a discussion of the challenges associated with metal and metal oxide NPs.

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Adapted from reference [6] with permission)

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(Adapted from reference [182] with permission)

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Funding

This manuscript was funded by a NASA EPSCoR Rapid Response Research (R3) program award 22-2022 R30015.

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Authors and Affiliations

  1. School of Biomedical Engineering, University of Sydney, Camperdown, NSW, 2006, Australia

    Ghazal Shineh

  2. Biomaterial Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, Iran

    Mohammadmahdi Mobaraki

  3. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

    Elham Afzali

  4. Molecular Science and Nanotechnology, Louisiana Tech University, Ruston, LA, 71272, USA

    Femi Alakija, Zeinab Jabbari Velisdeh & David K. Mills

  5. School of Biological Sciences and the Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Carson Taylor Hall, Room 128, Ruston, LA, 71272, USA

    Femi Alakija & David K. Mills

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  1. Ghazal Shineh
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Shineh, G., Mobaraki, M., Afzali, E. et al. Antimicrobial Metal and Metal Oxide Nanoparticles in Bone Tissue Repair. Biomedical Materials & Devices 2, 918–941 (2024). https://doi.org/10.1007/s44174-024-00159-3

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