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State-of-the-Art of Synthesized Exosomes and NPs-Based Biomimetic Nanoparticles for Wound Rehabilitation: A Review

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Abstract

Wound regeneration is a typical physiological mechanism consisting of a series of molecular and cellular processes that take place after the commencement of a tissue lesion to reestablish a barrier between the body and the external surroundings. Chronic non-healing wounds, on the other hand, require additional therapeutic qualities which could be obtained by using exosomes (Exo) and nanoparticles (NPs) to stimulate rapid and superior healing results. Many scientists have worked to understand the mechanisms of wound healing, and there are several reviews on the subject. To the best of our understanding, nevertheless, there has been little study on the utilization of Exo and NPs in wound healing. Our research aims to bridge that knowledge gap. This study first reviews previous studies on wounds and standard wound management methods. To close the gap in current research, we extensively discuss the state-of-the-art in engineered BioM-based wound healing approaches, including engineered exosome BioM-based procedures and nanoparticle-based BioMs for wound healing. Furthermore, current applications of BioM-based wound healing techniques are described. This study then closes by reviewing existing knowledge and discussing the multiple applications of synthesized BioM NPs for infectious wound healing.

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Abbreviations

antBA:

Antibacterial activity

ADMSCs:

Adipose-derived mesenchymal stem cells

ADSCs:

Adipose-derived stem cells

Ag NPs:

Silver nanoparticles

Biomimetics:

BioMs

BMSCs:

Bone marrow-derived MSCs

CBC:

Caryocar brasiliense Cambess

CNT-PDA:

Carbon nanotubes- dopamine

CO NPs:

Cerium oxide nanoparticles

EVs:

Extracellular vesicles

Exo:

Exosome

FT-IR:

Fourier transforms infrared

G-MSC:

Gingival- mesenchymal stem cells

GelMA:

Gelatin methacryloyl

GFs:

Growth factors

GT-PDA:

Gelati-dopamine

hADSCs:

Human adipose-derived stem cells

hucMSCs:

Human umbilical cord mesenchymal stem cells

LPS pre-MSCs:

LPS-preconditioned mesenchymal stromal cells

MSC-Exosomes:

Mesenchymal stem cell-derived exos

MPO:

Mentha pulegium essential oil

N-SuC NPs:

N-succinyl chitosan

NanoTech:

Nanotechnology

NMeds:

Nanomedicines

NMats:

Nanomaterials

NPs:

Nanoparticles

NSLCs:

Nanostructured lipid carriers

Me NPs:

Metal nanoparticles

PECE:

Poly (ethylene glycol)-poly(ε-caprolactone)-poly (ethylene glycol)

PHPV:

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

rPDA:

Reduced polydopamine

SA:

Sodium alginate

SeNPs:

Selenium Nanoparticles

SLi NPs:

Solid Lipid NPs

SMSCs:

Synovium mesenchymal stem cells

XRD:

X-ray diffraction

ZnO NP:

Zinc oxide nanoparticles

ZnO/SA:

Zinc oxide/sodium alginate

ZnO/Mgt-NCs:

Zn O/Magnetite-based nanocomposites

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  1. School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, People’s Republic of China

    Eliasu Issaka

  2. International Development, Community, and Environment, Clark University, Worcester, MA, 01610, USA

    Eliasu Issaka

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Issaka, E. State-of-the-Art of Synthesized Exosomes and NPs-Based Biomimetic Nanoparticles for Wound Rehabilitation: A Review. Biomedical Materials & Devices 2, 241–274 (2024). https://doi.org/10.1007/s44174-023-00112-w

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