Abstract
Cholesterol ester transfer protein is a plasma glycoprotein synthesized by the liver. Inhibitors of this protein have been researched to treat dyslipidemia. The purpose of this study was to use the computer-aided drug design technique to screen the structures of compounds from the traditional Chinese medicine database and optimize them as new cholesterol-lowering drugs. Molecular docking using 248 chemical compositions of traditional Chinese medicines with cholesterol ester transfer protein was performed. The parent structure “resveratrol” was selected and optimized as the matrix structure. A series of 4-[2-(3,5-dimethoxy-phenyl)-vinyl]-phenylamine analogues were synthesized and characterized by spectroscopic and spectrometric methods.
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Funding
This study was supported by grants from the Tianjin science and technology planning project (18ZXJMTG00250) and the foundation from Logistics College of Chinese People’s Armed Police Forces (WHB201710).
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XHL, XH, and QZ participated in study concept and design, acquisition of data, analysis and interpretation of data, and critical revision of the manuscript for important intellectual content. XHL, XH, and MYZ carried out drug design, pharmaceutical synthesis, and analyzed the data. QZ, XH, and YZ participated in in vivo antihyperlipidemic tests and participated in drafting the manuscript. All authors reviewed the final manuscript.
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Lin, X., Zhang, Q., Zhang, Jy. et al. Structure-Activity Relationship and Pharmacological Evaluation of 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenylacetamide as Cholesterol Ester Transfer Protein Inhibitor. Rev. Bras. Farmacogn. 30, 350–356 (2020). https://doi.org/10.1007/s43450-020-00022-8
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DOI: https://doi.org/10.1007/s43450-020-00022-8