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“Add-Ons” for Assisted Reproductive Technology: Do Patients Get Honest Information from Fertility Clinics’ Websites?

  • Infertility: Original Article
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Abstract

“Add-on” procedures are actively promoted on some fertility clinic websites as proven means to improve IVF success rates, especially for couples with repeated implantation/IVF failures. However, the actual contribution of these interventions to live birth rates remains inconclusive. At present, little is known about the type and quality of the information provided on the IVF clinics’ websites regarding the merits of “add-ons.” A systematic evaluation of the quality of information on “add-on” procedures in fertility clinic websites was performed using 10-criteria structured questionnaire. We included English language websites that presented in the Google.com search engine after typing the following key-words:“endometrial scratching”(ES), “intralipid infusions”(ILI), “assisted hatching”(AHA), “PGT-A,” or “PGS”. In total, 254 websites were evaluated. In most cases, an accurate description of the “add-on” procedures was provided (78.8%). However, only a minority (12%) reported their undetermined effectiveness. The use of PGT-A was more often encouraged (52.8%) than ES (23.6%) and AHA (16%). The cost was infrequently presented (6.9%). Scientific references were only rarely provided for ILI, versus 12.7% for ES, 4.0% for AHA, and 5.6% for PGT-A. The information entry date was often missing. None of the websites reported the clinic’s pregnancy-rate following the “add-on” procedures. Information on “add-ons” available to patients from IVF clinic websites is often inaccurate. This could perpetuate false myths among infertile patients about these procedures and raises concern regarding possible commercial bias. It is imperative that IVF clinic websites will better communicate the associated risks and uncertainties of “add-ons” to prospective patients.

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Authors and Affiliations

  1. Reproductive Medicine Unit, ASST Santi Paolo e Carlo - San Paolo University Hospital, 20142 via di Rudinì, 8, Milan, Italy

    Valentina Galiano, Emanuele Garzia & Patrizia Sulpizio

  2. Infertility and IVF Unit - Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Ramat Gan, Israel

    Valentina Galiano, Raoul Orvieto, Ronit Machtinger & Ravit Nahum

  3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Raoul Orvieto, Ronit Machtinger, Ravit Nahum & Daniel Seidman

  4. Department of Obstetrics and Gynecology, ASST Santi Paolo e Carlo - San Paolo University Hospital, Milan, Italy

    Anna Maria Marconi

  5. Assuta IVF Unit, Tel-Aviv, Israel

    Daniel Seidman

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  1. Valentina Galiano
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Contributions

All authors’ agreed with the submission of the manuscript.

V.G. and D.S. managed the project. V.G. acquired the data.

V.G., D.S., R.O., E.G., and R.M. drafted and finalized the manuscript.

All the authors gave final approval to the final version to be published.

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Correspondence to Valentina Galiano.

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Galiano, V., Orvieto, R., Machtinger, R. et al. “Add-Ons” for Assisted Reproductive Technology: Do Patients Get Honest Information from Fertility Clinics’ Websites?. Reprod. Sci. 28, 3466–3472 (2021). https://doi.org/10.1007/s43032-021-00601-7

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  • DOI: https://doi.org/10.1007/s43032-021-00601-7

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