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Effects of photobiomodulation therapy in dentoalveolar-derived mesenchymal stem cells: a review of literature

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Abstract

This review aims to present and discuss the published data on the application of photobiomodulation therapy (PBMT) on cultured cells, including dentoalveolar-derived mesenchymal stem cells (ddMSCs). The knowledge of the effects of PBMT on ddMSCs is of importance for future application in tissue engineering approaches aiming to regenerate missing dental tissues, among others. The tissue engineering, which is based on the triad stem cells, growth factors, and scaffolds, presents shortcomings that could be circumvented by the effects of the PBMT. Thus, our research group has proposed the PBMT as a fourth element of tissue engineering. This proposition is based on the published data on the effects of PBMT on different cell types, including ddMSCs. Future perspectives on PBMT and ddMSCs will be presented showing translational studies of tissue regeneration induced by PBMT. The experience of our research group supported by other studies of the literature shows the beneficial effects of PBMT. Moreover, this review will show that PBMT on ddMSCs and tissue regeneration is still a huge field for future investigations not only in vitro but also in vivo.

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References

  1. Anders JJ, Lanzafame RJ, Arany PR (2015) Low-level light/laser therapy versus photobiomodulation therapy. Photomed Laser Surg 33:183–184. doi:10.1089/pho.2015.9848

    Article  PubMed  PubMed Central  Google Scholar 

  2. Borowski M, Stein GS (2011) Introduction to pluripotent stem cells: biology and applications. In: Stein GS, Borowski MA, Luong MX, Shi MJ, Smith KP, Vasquez P (eds) Human stem cell technology and biology, 1st edn. Willey-Blackwell, New York, pp 3–7

    Google Scholar 

  3. Xinaris C, Morigi M, Benedetti V, Imberti B, Fabricio AS, Squarcina E, Benigni A, Gagliardini E, Remuzzi G (2013) A novel strategy to enhance mesenchymal stem cell migration capacity and promote tissue repair in an injury specific fashion. Cell Transplant 22:423–436. doi:10.3727/096368912X653246

    Article  PubMed  Google Scholar 

  4. Pereira AN, Eduardo Cde P, Matson E, Marques MM (2002) Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med 31:263–267

    Article  PubMed  Google Scholar 

  5. Eduardo Fde P, Bueno DF, de Freitas PM, Marques MM, Passos-Bueno MR, Eduardo Cde P, Zatz M (2008) Stem cell proliferation under low intensity laser irradiation: a preliminary study. Lasers Surg Med 40:433–438. doi:10.1002/lsm.20646

    Article  PubMed  Google Scholar 

  6. Damante CA, De Micheli G, Miyagi SP, Feist IS, Marques MM (2009) Effect of laser phototherapy on the release of fibroblast growth factors by human gingival fibroblasts. Lasers Med Sci 24:885–891. doi:10.1007/s10103-008-0582-y

    Article  PubMed  Google Scholar 

  7. Moreira MS, Velasco IT, Ferreira LS, Ariga SK, Abatepaulo F, Grinberg LT, Marques MM (2011) Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury. J Photochem Photobiol B 105:207–215. doi:10.1016/j.jphotobiol.2011.09.005

    Article  PubMed  Google Scholar 

  8. Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, Mooney JD (2014) Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Sci Transl Med 6:238ra69. doi:10.1126/scitranslmed.3008234

    Article  PubMed  PubMed Central  Google Scholar 

  9. AlGhamdi KM, Kumar A, Moussa NA (2012) Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells. Lasers Med Sci 27:237–249. doi:10.1007/s10103-011-0885-2

    Article  PubMed  Google Scholar 

  10. Azevedo LH, de Paula EF, Moreira MS, de Paula EC, Marques MM (2006) Influence of different power densities of LILT on cultured human fibroblast growth: a pilot study. Lasers Med Sci 21:86–89

    Article  PubMed  Google Scholar 

  11. Meneguzzo DT, Eduardo CP, Ribeiro MS, Marques MM (2008) Influence of the fractioned irradiation energy in the phototherapy with low intensity laser on the growth of human dental pulp fibroblasts. Proc of SPIE 6846:68460A-1-9. doi:10.1117/12.761220

    Google Scholar 

  12. Eduardo FP, Mehnert DU, Monezi TA, Zezell DM, Schubert MM, Eduardo CP, Marques MM (2007) Cultured epithelial cells response to phototherapy with low intensity laser. Lasers Surg Med 39:365–372

    Article  PubMed  Google Scholar 

  13. Fujihara NA, Hiraki KR, Marques MM (2006) Irradiation at 780 nm increases proliferation rate of osteoblasts independently of dexamethasone presence. Lasers Surg Med 38:332–336

    Article  PubMed  Google Scholar 

  14. Volpato LE, de Oliveira RC, Espinosa MM, Bagnato VS, Machado MA (2011) Viability of fibroblasts cultured under nutritional stress irradiated with red laser, infrared laser, and red light-emitting diode. J Biomed Opt 16:075004. doi:10.1117/1.3602850

    Article  PubMed  Google Scholar 

  15. Basso FG, Turrioni AP, Almeida LF, Soares DG, Oliveira CF, Hebling J, de Souza Costa CA (2016a) Nutritional deprivation and LPS exposure as feasible methods for induction of cellular—a methodology to validate for vitro photobiomodulation studies. J Photochem Photobiol B 159:205–210. doi:10.1016/j.jphotobiol.2016.04.001

    Article  PubMed  Google Scholar 

  16. Peplow PV, Chung TY, Baxter GD (2010) Laser photobiomodulation of proliferation of cells in culture: a review of human and animal studies. Photomed Laser Surg 28:S3–40. doi:10.1089/pho.2010.2771

    Article  PubMed  Google Scholar 

  17. Góralczyk K, Szymańska J, Szot K, Fisz J, Rość D (2016) Low-level laser irradiation effect on endothelial cells under conditions of hyperglycemia. Lasers Med Sci 31:825–831. doi:10.1007/s10103-016-1880-4

    Article  PubMed  PubMed Central  Google Scholar 

  18. Basso FG, Soares DG, Pansani TN, Cardoso LM, Scheffel DL, de Souza Costa CA, Hebling J (2016b) Proliferation, migration, and expression of oral-mucosal-healing-related genes by oral fibroblasts receiving low-level laser therapy after inflammatory cytokines challenge. Lasers Surg Med. doi:10.1002/lsm.22553

    PubMed  Google Scholar 

  19. Sousa LR, Cavalcanti BN, Marques MM (2009) Effect of laser phototherapy on the release of TNF-alpha and MMP-1 by endodontic sealer-stimulated macrophages. Photomed Laser Surg 27:37–42. doi:10.1089/pho.2007.2220

    Article  PubMed  Google Scholar 

  20. Dantas CM, Vivan CL, Ferreira LS, Freitas PM, Marques MM (2010) In vitro effect of low intensity laser on the cytotoxicity produced by substances released by bleaching gel. Braz Oral Res 24:460–466

    Article  PubMed  Google Scholar 

  21. Hou J, Zhang H, Yuan X, Li J, Wei Y, Hu S (2008) In vitro effects of low-level laser irradiation for bone marrow mesenchymal stem cells: proliferation, growth factors secretion and myogenic differentiation. Lasers Surg Med 40:726–733. doi:10.1002/lsm.20709

    Article  PubMed  Google Scholar 

  22. Ginani F, Soares DM, Barreto MP, Barboza CA (2015) Effect of low-level laser therapy on mesenchymal stem cell proliferation: a systematic review. Lasers Med Sci 30:2189–2194. doi:10.1007/s10103-015-1730-9

    Article  PubMed  Google Scholar 

  23. Fekrazad R, Asefi S, Allahdadi M, Kalhori KA (2016) Effect of photobiomodulation on mesenchymal stem cells. Photomed Laser Surg 34:533–542

    Article  PubMed  Google Scholar 

  24. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 97:13625–13630

    Article  PubMed  PubMed Central  Google Scholar 

  25. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S (2003) SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 100:5807–5812

    Article  PubMed  PubMed Central  Google Scholar 

  26. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149–155

    Article  PubMed  Google Scholar 

  27. Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT (2008) Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod 34:166–171. doi:10.1016/j.joen.2007.11.021

    Article  PubMed  PubMed Central  Google Scholar 

  28. Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Möhl C, Sippel C, Hoffmann KH (2005) Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol 24:155–165

    Article  PubMed  Google Scholar 

  29. Marrelli M, Paduano F, Tatullo M (2013) Cells isolated from human periapical cysts express mesenchymal stem cell-like properties. Int J Biol Sci 9:1070–1078. doi: 10.7150/ijbs.6662. eCollection 2013

  30. La Noce M, Paino F, Spina A, Naddeo P, Montella R, Desiderio V, De Rosa A, Papaccio G, Tirino V, Laino L (2014) Dental pulp stem cells: state of the art and suggestions for a true translation of research into therapy. J Dent 42:761–768. doi:10.1016/j.jdent.2014.02.018

    Article  PubMed  Google Scholar 

  31. Marques MM, Diniz IM, de Cara SP, Pedroni AC, Abe GL, D'Almeida-Couto RS, Lima PL, Tedesco TK, Moreira MS (2016) Photobiomodulation of dental derived mesenchymal stem cells: a systematic review. Photomed Laser Surg 34:500–508

    Article  PubMed  Google Scholar 

  32. Pereira LO, Longo JPF, Azevedo RB (2012) Laser irradiation did not increase the proliferation or the differentiation of stem cells from normal and inflamed dental pulp. Arch Oral Biol 57:1079–1085. doi:10.1016/j.archoralbio.2012.02.012

    Article  PubMed  Google Scholar 

  33. Turrioni APS, Basso FG, Montoro LA, De Almeida LDFD, Costa CADS, Hebling J (2014) Phototherapy up-regulates dentin matrix proteins expression and synthesis by stem cells from human-exfoliated deciduous teeth. J Dent 42:1292–1299. doi:10.1016/j.jdent.2014.07.014

    Article  PubMed  Google Scholar 

  34. Soares DM, Ginani F, Henriques ÁG, Barboza CA (2015) Effects of laser therapy on the proliferation of human periodontal ligament stem cells. Lasers Med Sci 30:1171–1174. doi:10.1007/s10103-013-1436-9

    Article  PubMed  Google Scholar 

  35. Zaccara IM, Ginani F, Mota-Filho HG, Henriques ÁC, Barboza CA (2015) Effect of low-level laser irradiation on proliferation and viability of human dental pulp stem cells. Lasers Med Sci 30:2259–2264. doi:10.1007/s10103-015-1803-9

    Article  PubMed  Google Scholar 

  36. Diniz IM, Matos AB, Marques MM (2015a) Laser phototherapy enhances mesenchymal stem cells survival in response to the dental adhesives. Sci World J 2015:671789. doi:10.1155/2015/671789

    Article  Google Scholar 

  37. Ferreira LS, Destro MFSS, Maranduba C, Miyagi SPH, Marques MM (2012a) Effect of laser phototherapy on gene expression of stem cell markers of human dental pulp cells. Med Oral Patol Oral Cir Bucal 17:S100. doi:10.4317/medoral.17643599

    Article  Google Scholar 

  38. Ferreira LS, Cai S, Barros JA, Patel SA, Chen W, Marques MM (2012b) Effects of laser phototherapy and growth factors PDGF and BMP2 on the odontogenic differentiation of dental pulp stem cells. Med Oral Patol Oral Cir Bucal 17:S101. doi:10.4317/medoral.17643600

    Article  Google Scholar 

  39. Lopez TC, Diniz IM, Ferreira LS, Marchi J, Borges R, de Cara SP, D'Almeida-Couto R, Marques MM (2015) Bioactive glass plus laser phototherapy as promise candidates for dentine hypersensitivity treatment. J Biomed Mater Res B Appl Biomater. doi:10.1002/jbm.b.33532

    PubMed  Google Scholar 

  40. Borzabadi-Farahani A (2016) Effect of low-level laser irradiation on proliferation of human dental mesenchymal stem cells; a systemic review. J Photochem Photobiol B 162:577–582. doi:10.1016/j.jphotobiol.2016.07.022

    Article  PubMed  Google Scholar 

  41. Fernandes AP, Junqueira Mde A, Marques NC, Machado MA, Santos CF, Oliveira TM, Sakai VT (2016) Effects of low-level laser therapy on stem cells from human exfoliated deciduous teeth. J Appl Oral Sci 24:332–337. doi:10.1590/1678-775720150275

    Article  PubMed  PubMed Central  Google Scholar 

  42. Moura Netto C, Ferreira LS, Maranduba CM, Mello-Moura AC, Marques MM (2016) Low-intensity laser phototherapy enhances the proliferation of dental pulp stem cells under nutritional deficiency. Braz Oral Res. doi:10.1590/1807-3107BOR-2016.vol30.0080

    PubMed  Google Scholar 

  43. Diniz IMA (2015b) Odonto/osteogenic differentiation of photomodulated mesenchymal stem cells in BMP-4 loaded hydrogel. Thesis, Universidade de São Paulo

  44. Pellicioli AC, Martins MD, Dillenburg CS, Marques MM, Squarize CH, Castilho RM (2014) Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of rapamycin signaling pathway. J Biomed Opt 19:028002. doi:10.1117/1.JBO.19.2.028002

    Article  PubMed  Google Scholar 

  45. de Sá SF, Almeida PN, Rettore JV, Maranduba CP, de Souza CM, de Souza GT, Zanette Rde S, Miyagi SP, Santos Mde O, Marques MM, Maranduba CM (2012) Toward personalized cell therapies by using stem cells: seven relevant topics for safety and success in stem cell therapy. J Biomed Biotechnol 2012:758102. doi:10.1155/2012/758102

    Google Scholar 

  46. Wei F, Qu C, Song T, Ding G, Fan Z, Liu D, Liu Y, Zhang C, Shi S, Wang S (2012) Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity. J Cell Physiol 9:3216–3224. doi:10.1002/jcp.24012

    Article  Google Scholar 

  47. Pedroni ACF (2016) Effect of laserphototherapy associated or not to vitamin C in the induction of cell sheets of human dental pulp stem cells. Dissertation, Universidade de São Paulo

  48. Bartold PM, Gronthos S, Ivanovski S, Fisher A, Hutmacher DW (2016) Tissue engineered periodontal products. J Periodontal Res 51:1–15. doi:10.1111/jre.12275

    Article  PubMed  Google Scholar 

  49. Kim K, Lee CH, Kim BK, Mao JJ (2010) Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res 89:842–847. doi:10.1177/0022034510370803

    Article  PubMed  PubMed Central  Google Scholar 

  50. Moreira MS, Diniz IM, Rodrigues MF, de Carvalho RA, de Almeida Carrer FC, Neves II, Gavini G, Marques MM (2016) In vivo experimental model of orthotopic dental pulp regeneration under the influence of photobiomodulation therapy. J Photochem Photobiol B 166:180–186. doi:10.1016/j.jphotobiol.2016.11.022

    Article  PubMed  Google Scholar 

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Restorative Dentistry, School of Dentistry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

    Márcia Martins Marques, Gabriela Laranjeira Abe, Ana Clara Fagundes Pedroni & Ivana Márcia Alves Diniz

  2. Department of Dentistry, School of Dentistry, Faculdades Metropolitanas Unidas (FMU), Sao Paulo, Sao Paulo, Brazil

    Sueli Patricia Harumi Miyagi de Cara

  3. Department of Biodentistry, School of Dentistry, Ibirapuera University, Sao Paulo, Sao Paulo, Brazil

    Maria Stella Moreira

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  1. Márcia Martins Marques
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  2. Sueli Patricia Harumi Miyagi de Cara
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  3. Gabriela Laranjeira Abe
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  4. Ana Clara Fagundes Pedroni
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  5. Ivana Márcia Alves Diniz
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  6. Maria Stella Moreira
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Correspondence to Márcia Martins Marques.

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Marques, M.M., de Cara, S.P.H.M., Abe, G.L. et al. Effects of photobiomodulation therapy in dentoalveolar-derived mesenchymal stem cells: a review of literature. Laser Dent Sci 1, 1–7 (2017). https://doi.org/10.1007/s41547-017-0002-3

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  • DOI: https://doi.org/10.1007/s41547-017-0002-3

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