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Unlocking Diversity: From Simple to Cutting-Edge Synthetic Methodologies of Bis(indolyl)methanes

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Abstract

From a synthetic perspective, bis(indolyl)methanes have undergone extensive investigation over the past two to three decades owing to their remarkable pharmacological activities, encompassing anticancer, antimicrobial, antioxidant, and antiinflammatory properties. These highly desirable attributes have spurred significant interest within the scientific community, leading to the development of various synthetic strategies that are not only more efficient but also ecofriendly. This synthesis-based literature review delves into the advancements made in the past 5 years, focusing on the synthesis of symmetrical as well as unsymmetrical bis(indolyl)methanes. The review encompasses a wide array of methods, ranging from well-established techniques to more unconventional and innovative approaches. Furthermore, it highlights the exploration of various substrates, encompassing readily available chemicals such as indole, aldehydes/ketones, indolyl methanols, etc. as well as the use of some specific compounds as starting materials to achieve the synthesis of this invaluable molecule. By encapsulating the latest developments in this field, this review provides insights into the expanding horizons of bis(indolyl)methane synthesis.

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Acknowledgements

The authors are grateful to the Department of Chemistry, M.L.S.U. Udaipur, Rajasthan, India, for providing necessary library facilities. P. Teli is very grateful to the Council for Scientific and Industrial Research (CSIR) (file no. 09/172(0099)2019-EMR-I, New Delhi) for the award of a Senior Research Fellowship as financial support.

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  1. Department of Chemistry, Synthetic Organic Chemistry Laboratory, MLSU, Udaipur, Rajasthan, India

    Pankaj Teli, Shivani Soni, Sunita Teli & Shikha Agarwal

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P.T. searched and sorted the research articles and wrote the manuscript. S.S. and S.T. helped in editing and drawing the schemes. S.A. contributed to guiding, writing, revising, and overall literature review.

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Teli, P., Soni, S., Teli, S. et al. Unlocking Diversity: From Simple to Cutting-Edge Synthetic Methodologies of Bis(indolyl)methanes. Top Curr Chem (Z) 382, 8 (2024). https://doi.org/10.1007/s41061-024-00454-z

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