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A Brief Review of the Pathophysiology of Non-melanoma Skin Cancer and Applications of Interpenetrating and Semi-interpenetrating Polymer Networks in Its Treatment

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Abstract

Skin cancers especially non-melanoma skin cancer or nonmelanocytic skin cancer (NMSC) are the fastest-growing type of cancer in the Caucasian population. The costs of these diseases are high, and treatments are invasive or have adverse effects. Currently, smart biomaterials present an alternative for adequate treatment for better dose control, higher cell-specify and less side effects. Interpenetrating and semi-interpenetrating polymer networks, which include hydrogels, are smart materials composed of the entanglement of two or more polymers. These biomaterials possess with tuneable properties including elasticity, biocompatibility and biodegradation, and therefore are ideal materials for artificial scaffolds for tissue regeneration, and controlled drug delivery systems, both of which have important applications in skin cancer. The overall idea of this text is to present the factors that trigger the development and current treatment of NMSC. Also, it is discussed what biomaterials such as interpenetrating polymer networks are, their properties and advantages, and the new role that are playing in the treatment for NMSC and other pathologies.

Lay Summary

Nom-melanoma skin cancer is increasing its incidence worldwide and this trend is expected to continue. Treatment is expensive and either invasive or presents adverse effects. Interpenetrating and semi-interpenetrating polymer networks are smart biomaterials with tuneable properties that can be used to improve the treatment of these cancers and other pathologies.

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Funding

This work was supported by SEP-PRODEP award 511-6/17-9932 postdoctoral funding 993201.

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  1. Center for Research in Medical Sciences (CICMED), Autonomous University of the State of Mexico, 205 Venustiano Carranza, Universidad C.P., 50130, Toluca, Mexico

    Angelica Jimenez-Rosales & Miriam Veronica Flores-Merino

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  1. Angelica Jimenez-Rosales
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  2. Miriam Veronica Flores-Merino
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Correspondence to Angelica Jimenez-Rosales.

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Jimenez-Rosales, A., Flores-Merino, M.V. A Brief Review of the Pathophysiology of Non-melanoma Skin Cancer and Applications of Interpenetrating and Semi-interpenetrating Polymer Networks in Its Treatment. Regen. Eng. Transl. Med. 4, 187–205 (2018). https://doi.org/10.1007/s40883-018-0061-3

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